Urinalysis Flashcards
proteinuria
RBCs, RBC casts
1-2 weeks post infection
acute glomerulonephritis
S. pyogenes
cellular, waxy, broad casts
glycosuria
chronic glomerulonephritis
anti-glomerular basement membrane
Goodpasture’s
Antineutrophilic cytoplasmic antibody (ANCA)
Wegner’s granulomatosis
decrease in platelets
stool occult blood
RBC casts
children post viral infection
Henoch-Schönlein Purpura
increased cellularity in the subendothelial cells of the mesangium (interstitial area of Bowman’s capsule)
Membranoproliferative Glomerulonephritis (MPGN)
Immune IgA complexes deposited on the glomerular membrane
glycosuria, cellular, waxy and broad casts
IgA nephropathy
heavy proteinuria
hypoalbuminemia
RTEs, OFBs, fatty casts, waxy casts
nephrotic syndrome
Disruption of podocytes in certain areas of glomeruli associated with heroin, analgesic abuse, and AIDS
Focal Segmental Glomerulosclerosis
Inherited sex-linked or autosomal genetic disorder of collagen production affecting the glomerular basement membrane
Alport’s syndrome
Damage to the RTE cells produced by ischemia
acute tubular necrosis
General failure of tubular reabsorption
possible cystine crystals
Fanconi’s syndrome
differentiates upper from lower UTI
WBC casts
urine eosinophils, no bacteria, WBCs, WBC casts
skin rash
acute interstitial nephritis
Mousy odor to the urine
disrupts the normal pathway of phenylalanine to tyrosine
phenylketonuria
Inherited defect vs metabolic defect (tyrosine or leucine crystals)
tyrosyluria
dark urine
malignancy
melanuria
Reddish-stained disposable diapers
Brown pigment becomes deposited in the body tissues
Homogentisic acid accumulates
alkaptonuria
keto acids accumulate in the blood and urine
maple syrup urine disease
“smelly feet” odor to urine
isovaleric acidemia
blue diaper syndrome
indicanuria/Hartnup disease
Sulfur smell to urine and cystine crystals present
cystinuria
Mucopolysaccharide Disorders
Hurler syndrome
Hunter syndrome
Sanfilippo Syndrome
many uric acid crystals
sandy diaper
self-destruction
Lesch-Nyhan disease
Disorder of purine metabolism
Lesch-Nyhan disease
carbs in urine
melituria
pellicle formation in CSF
tubercular meningitis
CSF lactate >35
bacterial meningitis
CSF gluatmine >35
disturbance of consciousness
Increased IgG index
bands in CSF, not in serum
MS
2 types of body fluid collections
transudate (clear)
exudate (cloudy)
aligned with slow vibration; fast light is impeded, producing a yellow color (negative birefringence)
monosodium urate crystals
gout vs pseudogout crystals
gout: MSU
pseudogout: CPPD
impede the slow light producing a blue color (positive birefringence)
calcium pyrophosphate dihydrate
yellow amniotic fluid
HDFN
green amniotic fluid
meconium
red-brown amniotic fluid
fetal death
used to determine if bilirubin is low enough for fetus to be safe
Lily graph
Reported in terms of multiples of the median (MoM)
AFP for neural tube defects
primary component of the surfactants
lecithin
When a L/S ratio is —— at preterm delivery, baby is usually considered safe
> 2.0
Shake test: Amniotic fluid is mixed with ——– and shaken for 15 seconds
95% ethanol
Densely packed layers of phospholipids that represent a storage form of pulmonary surfactant.
lamellar bodies
The number of ———– counted in amniotic fluid correlates with the amount of phospholipid present in the fetal lungs.
lamellar bodies
distinguish between the presences of fetal blood or maternal blood in an infant’s stool or vomitus
APT test
hemocytometer count calculation
(avg # cells)(10)(dilution factor)/area counted, mm2
normal random urine pH
4.5-8.0
Occurs in vertical position, disappears in horizontal position
orthostatic proteinuria
principle of protein detection on urine strip
protein error of indicators
Sulfosalicylic Acid (SSA) Precipitation
urine protein confirmatory
renal threshold for glucose
160-180 mg/dL
causes false negatives on glucose, blood and bilirubin pads on urine stick
ascorbic acid
Copper Reduction Test (Clinitest/Benedict’s Test)
urine glucose confirmatory
3 ketones
Beta-hydroxybutyrate (78%)
Acetoacetic acid (20%)
Acetone (2%)
acetest
urine ketones confirmatory
urine strip blood pad based on…
pseudoperoxidase activity of hemoglobin
Ictotest
urine bilirubin confirmatory
best urine collection for urobilinogen
2-4 pm
Ehrlich’s aldehyde reaction
urine urobilinogen
Griess reaction
nitrites in urine
catalyzes the hydrolysis of an acid ester embedded on a pad
leukocyte esterase
SG not affected by radiographic dye
urine strip
at RT, urine should be examined before — hours
2
Sternheimer-Malbin stain
Identifies WBCs, epithelial cells, and casts in urine
0.5% Toluidine Blue stain
Differentiates WBCs and renal tubular epithelial cells in urine
does not stain with Oil Red O or Sudan III
cholesterol
Hansel stain
Identifies urinary eosinophils
lymphs in urine
renal graft rejection
RTE cells filled with absorbed lipids
oval fat bodies
major component of hyaline casts
uromodulin/Tamm-Horsfall protein
Represent extreme urinary stasis
waxy casts
Represent extreme urinary stasis and tubular distension
broad casts
normal crystals in acidic urine
amorphous urates
uric acid
acid urates
sodium urates
calcium oxalate
normal crystals in alkaline urine
amorphous phosphates
triple phosphate
calcium phosphate
calcium carbonate
ammonium biurate
coffin lid
triple phosphate
thorny apple
ammonium biurate
envelope crystal
calcium oxalate
hexagonal crystals
cystine
Rectangular plate with a notch in one or more corners
cholesterol crystals
Yellow-brown spheres
Concentric circles and radial striations
leucine crystals
Fine colorless to yellow needles
Clusters or rosettes
tyrosine crystals
Clumped needles/granules with amber color
bilirubin crystals
Elongated prisms or plates
Blunt point on one end
hippuric acid crystals