Upper GI (stomach and oesophagus) Flashcards
describe the dysphagia associated with motility issues
intermittent
both solids and liquids from outset
non-progressive
what are the features of systemic sclerosis
calcinosis Raynauds oEsophageal dysmotility sclerodactyly telangiectasia (CREST)
oesophageal dysmotility + blurred vision / ptosis
myasthenia gravis
1st line Ix for dysphagia
OGD
+ FBC
Ix required if consideration for fundoplication
ambulatory oesophageal pH and manometry studies
tx benign oesophageal stricture
dilation and high dose PPI
triad of plummer vinson
oesophageal webs + glossitis + iron deficiency anaemia
in post-menopausal wmoen
tx of plummer vinson
dilation and iron supplement
virus associated with SCC of oesophagus
HPV
cancer of lower 1/3 oesophagus
adenocarcinoma
ix oesophageal cancer
OGD + biopsy
initial staging in oesophageal cancer
CTCAP
staging in oesophageal cancer if localised disease seen on CTCAP
EUS +/- FNA
staging in oesophageal cancer if metastasis/not localised seen on CTCAP
PET CT
or laparoscopy to detect peritoneal disease
tx localised SCC oesophageal cancer
radical chemo/radio
best treatment of oesophageal cancer
surgery - endoscopic resection or oesophagectomy (stage 2 and above)
diagnositic test achalasia
oesophageal manometry
barium swallow of achalasia
birds beak
pharmacological tx achalasia
nitrates or CCB
Botox - if not suitable for surgery
1st line surgical tx of achalasia
endoscopic balloon dilation
definitive surgical tx of achalasia if recurrent or persistent symptoms
hellers cardiomyotomy + lifelong PPI
CXR/barium swallow of Diffuse oesophageal spasms
corkscrew appearance/nut cracker
1st line ix for Diffuse oesophageal spasms
OGD
young male
atopic
OGD - mucosal furrows
schatzi rings
eosinophilic oesophagitis
retrosternal discomfort made worse with eating/lying down
odynophagia
GORD
ix of GORD
usually trial of treatment before OGD unless red flags
> 55 symptoms > 4 weeks weight loss dysphagia persistent symptoms despite treatment
lifestyle advice for GORD
o Diet change, weight loss, reduce alcohol and smoking.
o Small, regular, meals, avoid eating before going to bed.
o Elevate the end of the bed
review meds
tx GORD in patients who have not had OGD
PPI for 1 months
tx GORD in patients who have oesophagitis on OGD
full dose PPI 1-2 months
- if this works then low dose
- if not then double dose for 1 month
tx GORD in patients who do not have oesophagitis on GORD
full dose PPI 1 month
- if no response then H2 receptor blocker (ranitidine)
Risk of PPI
risk of osteoporosis
what is red velvety oesophageal mucosa on OGD
barretts
how often should patients with oesophageal metaplasia but not dysplasia get endoscopy
3-5 years
tx oesophageal dysplasia (barretts)
endoscopic mucosal resection + RFA
most sensitive investigation for hiatus hernia
barium swallow
1st line ix for hiatus hernia
OGD
tx hiatus hernia
nissen fundoplication
2 tests for H pylori
urea (carbon 13) breath test
or
H pylori stool antigen (primary care)
how long do PPI and antibiotics need to be stopped before H pulori test
ppi - 2 weeks
abx - 4 weeks
how long should PPI be stopped before OGD
2 weeks
what is used for repeat H pylori testing
breath test
do you do a repeat H pylori test if symptoms resolve
no
1st line ix for dyspepsia
H pylori or OGD
1st line tx of dyspepsia
medication review
lifestyle advice
antacid /alginate
tx for dyspepsia after lifestyle/medication if not needing OGD
full dose PPI for 1 month and / or test and treat for H pylori
what is the treatment for H pylori - normal and pen all
amoxicillin + clarithromycin + omeprazole 1 week
pen al - clarithromycin + metronidazole + omeprazole
ulcers that are sore when hungry
duodenal - more common
ulcers that are more sore when eating
gastric
ix peptic ulcer
H pylori
tx peptic ulcer H pylori +ve
H pylori eradication
tx peptic ulcer H pylori negative
PPI for 4 weeks
ix possible perforated peptic ulcer
erect CXR
what is a zollinger ellison syndrome and when it is seen
MEN1
tumour of pancreas/duodenum
produces gastrin leading to treatment resistant dyspepsia and steatorrhoea
ix for ZE syndrome
high fasting gastrin
MRI
what gastric cancer has the highest associated with H pylori
adenocarcinoma
adenocarcinoma on histology
signet ring
2 nodes seen in gastric cancer
virchows
sister mary joseph (periumbilical)
diagnostic ix for gastric cancer
OGD + biopsy
staging gastric cancer
CTCAP
tx gastric cancer in proximal 1/3 stomach
total gastrectomy
tx gastric cancer in distal 2/3 stomach
subtotal gastrectomy
what is the mainstay treatment of gastric cancer
surgery +/- chemo
tx functional dyspepsia
lifestyle
PPI PRN or lowest possible dose
dx gastropareisis
gastric scintigraphy
tx gastropareisis
prokinetic- domperidone, metoclopramide
anti emetic - prochlorperazine, ondansentron
stool if upper GI bleed will appear like what
black sticky smelly tar like tool
blood marker that might indicate upper GI bleed
High urea out of proportion of creatinine
treatment variceal bleed
FTKAB
- FFP
- vitamin K
- terlipressin
- antibiotic prophylaxis - ciprofloxacin
- endoscopic band ligation
uncontrolled variceal haemorrhage
senstaken-blakemore tube
last line variceal bleed
TIPS
drug to reduce risk of further variceal bleed
propranolol
tx upper GI bleed due to peptic ulcer/gastritis
IV PPI infusion - given after OGD, not in acute phase, if evidence of non-variceal bleeding
endoscopic treatment on ulcer - adrenaline, thermal ablation, clipping
what should all patients with severe upper GI be offered
OGD immediately after resus, within 24 hours
general treatment of upper GI bleed
IV access, fluid resus, ABCDE
FFP - if low fibrinogen levels or high PT
prothrombin complex and vit K to warfarin patients actively bleeding