upper GI

Question 1

backbone of triple therapy

Answer 1

2 abx + PPI

Question 2

what happens when sodium bicarbonate interacts with stomach acid?

Answer 2

bubbles, expands

Question 3

syndrome cause by taking too much calcium carbonate

Answer 3

milk-alkali syndrome- nausea, headache, calcium stones

Question 4

which antacid causes diarrhea? constipation?

Answer 4

Mg- diarrhea

Al- constipation

Question 5

which antacid is useful in dialysis?

Answer 5

AlOH because it binds phosphate

Question 6

H2 blockers are most effective at decreasing-

Answer 6

basal acid secretion

Question 7

cimetidine interactions

Answer 7

2C9, 2C19, 3A4

Question 8

how are PPIs concentrated in the stomach

Answer 8

in parietal cells by pH trapping

Question 9

5 possible consequences of long term PPI use

Answer 9

fracture, C. diff, B12 def, pneumonia and hypomagnesemia

Question 10

which PPIs affect 2C9

Answer 10

esomeprazole and omeprazole

Question 11

MOA of sucralfate

Answer 11

at low pH, binds to damaged and ulcerated tissue, forming a physical barrier

Question 12

MOA of bismuth subsalicylate

Answer 12

at low pH, reacts with HCl to form bismuth oxychloride and salicylic acid

Question 13

unique SE of bismuth products

Answer 13

can turn stool and tongue black

Question 14

MOA of misoprostol (3)

Answer 14

PGE1 agonist that increase blood flow, increases mucus and decreases acid in stomach

Question 15

drug of choice for n/v in pregnancy

Answer 15

doxylamine and pyridoxine

Question 16

ADR of D2 antagonists

Answer 16

extrapryamidal symptoms

Question 17

best type of n/v med for motion sickness

Answer 17

anticholinergic or antihistamine

Question 18

4 typical anticholinergic SE

Answer 18

dry mouth, constipation, urinary retention, blurred vision

Question 19

MOA of aprepitant

Answer 19

substance P, NK1 antagonist