parasites

Question 1

MOA of chloroquine

Answer 1

inhibits heme polymerase

Question 2

unique ADR of chloroquine

Answer 2

visual disturbance

Question 3

unique ADR of quinine

Answer 3

cinchonism- tinnitus, vertigo, dafness, headache

blackwater fever- massive hemolysis, hemoglobinuria

Question 4

reserved for severe, life threatening malaria due to its ability to cause heart arrhythmia

Answer 4

quinidine

Question 5

drug of choice for malaria requiring parenteral therapy

Answer 5

artesunate

Question 6

1st line agent for treatment and prophylaxis of chloroquine-resistant sp

Answer 6

malarone (atovaquone + proguanil)

Question 7

What is coartem?

Answer 7

arthemether + lumefantrine

used PO after stabilized on IV artesenate

Question 8

cardiac ADR coartem

Answer 8

QT prolongation

Question 9

alternative agent for chloroquine-resistant prophylaxis

Answer 9

doxycycline

Question 10

drug that can be given in once weekly doses for prophylaxis

Answer 10

mefloquine

Question 11

ADR of mefloquine

Answer 11

neuropsych syndrome (depression, psychosis and seizure)- makes it 2nd line therapy

Question 12

only drug that targets liver form

Answer 12

primaquine

Question 13

primaquine causes hemolysis in pts with

Answer 13

G6PD

Question 14

2 luminal agents for E. histolytica

Answer 14

paromomycin and iodoquinol

Question 15

MOA of metronidazole

Answer 15

converted to toxic nitro radical in a process that is unique to anaerobic bacteria and parasites

Question 16

pregnancy recommendations for metronidazole

Answer 16

CI in 1st trimester

cat B in 2/3

Question 17

effect of metronidazole on warfarin

Answer 17

increases INR, due to presence of MTT

Question 18

unique ADR of metronidazole

Answer 18

metallic taste

Question 19

medication used for metronidazole-resistance

Answer 19

tinidazole

Question 20

MOA of albendazole

Answer 20

inhibits microtubule formation and depletes glycogen stores

Question 21

albendazole in pregnancy

Answer 21

CI

Question 22

MOA of PAM

Answer 22

depolarizing NM blocking agents leading to paralysis

Question 23

MOA of praziquantel

Answer 23

increases cell membrane permeability and eventual disintegration of parasite

Question 24

special cautions when taking praziquantel

Answer 24

swallow tablets whole

avoid driving for 2 days

Question 25

drug of choice for lice, scabies

Answer 25

permethrin

Question 26

MOA of permethrin

Answer 26

acts on nerve cell membrane, paralyzes parasite

Question 27

ADR of lindane if absorbed

Answer 27

neurologic toxicity

Question 28

crotamiton use

Answer 28

scabies only