asthma and allergies

Question 1

why is the use of LABA without ICS CI in asthma?

Answer 1

LABAs indice tolerance and down regulation of tissue response to SABA, therefore if patient has asthma attack SABA is not effective

Question 2

SE caused by xanthines (3)

Answer 2

CNS stimulation- seizures
Cardiovascular stimulation
diuretic effect

Question 3

MOA of xanthines

Answer 3

1- inhibit phosphodiesterase

2- inhibit adenosine A2 receptors

Question 4

MOA of anticholinergics

Answer 4

antagonize ACH to cause bronchodilation and increased mucociliary clearance

Question 5

LT modulator effects (3)

Answer 5

• inhibit bronchoconstriction
• decrease microvascular leakage
• inhibit influx of basophils and lymphocytes

Question 6

MOA of omalizumab

Answer 6

anti-IgE antibody that inhibits binding IgE to mast cells thereby preventing degranulation

Question 7

ADR of omalizumab

Answer 7

anaphylaxis (immediate or delayed)

Question 8

inhaled steroids increase the risk of … in COPD (2)

Answer 8

pneumonia

osteoporosis

Question 9

MOA of roflumilast

Answer 9

PDE4 inhibitor

Question 10

intranasal antihistamine

Answer 10

azelastine

Question 11

oral decongestants are CI if also taking what class of meds

Answer 11

MAO-I

Question 12

what 4 conditions can be exacerbated by use of oral decongestants?

Answer 12

hyperthyroidism, BPH, glaucoma, HTN

Question 13

drug of choice for allergic rhinitis

Answer 13

intranasal steroids