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pharm block 4 > fungals > Flashcards

fungals Flashcards

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1
Q

MOA of imidazoles

A

block ergosterol synthesis via C14-demthylase

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2
Q

non-fungal uses of ketoconazole (3)

A

prostate CA- decreases testosterone
cushings- decreases cortisol
hypercalcemia in Sarcoid- decreases active vit D

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3
Q

ADRs of ketoconazole (3)

A

GI upset, hepatotoxicity, decreased testosterone (gynecomastia, decreased libido, ED)

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4
Q

fluconazole elimination

A

renal *unique

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5
Q

ketoconazole interactions

A

3A4 inhibitor

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6
Q

fluconazole interactions

A

2C9, 2c19 and 3A4 inhibitor

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7
Q

2 unique ADRs of itraconazole

A

taste disturbance, heart failure

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8
Q

unique ADRs of voriconazole

A

can penetrate CNS- so can cause vision disturbance, photosensitivity, hallucinations

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9
Q

imidazoles pregnancy category

A

all are cat C

except voriconazole is cat D

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10
Q

posaconazole has better activity against-

A

mucor

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11
Q

MOA of echinocandins

A

disrupt cell wall synthesis via glucan

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12
Q

use of echinocandins

A

drugs of choice for invasive candidiasis

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13
Q

MOA of polyenes

A

bind to ergosterol and create holes in cell membrane

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14
Q

preferred drug for severe fungal infections in pregnancy

A

amphotericin B

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15
Q

3 types of ADRs for amphotericin B

A

infusion related- premedicate with NSAIDs, steroids, diphenhydramine
nephrotoxicity- premedicate with IV fluids
Hypokalemia

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16
Q

MOA of terbinafine

A

affects plasma membrane synthesis via squalene epoxidase

17
Q

terbinafine is the oral drug of choice for-

A

onychomycosis

18
Q

2 unique ADRs of terbinafine

A

taste disturbance, SJS

19
Q

drug class of nystatin

A

polyene

20
Q

MOA of griseofulvin

A

inhibits MT assembly

21
Q

to increase absorption of griseofulvin-

A

take with high fat meal

22
Q

MOA of flucytosine

A

converted to 5FU intracellularly, stops DNA synthesis

pharm block 4 (7 decks)

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