lower GI Flashcards
(28 cards)
drugs to induce remission in IBD
aminosalicylates and steroids
drugs for maintenance in IBD
aminosalicylates and thiopurines
drugs for refractory disease in IBD
cyclosporine and infliximab
MOA of aminosalicylates
block arachidonic acid metabolism to decrease inflammation
need to avoid sulfasalazine if what 2 allergies
sulfa or aspirin
need to avoid melamine if what allergy
aspirin
unique ADR of aminosalicylates
bone marrow suppression
MOA of thiopurines
inhibit purine synthesis and induce apoptosis of T cells
2 agents in thiopurine class
azathioprine and 6-MP
ADR of thiopurines
neutropenia and bone marrow suppression
MOA of cyclosporine
inhibits calcineurin to interfere with T cell transduction
ADR of cyclosporine
nephrotoxic
neurotoxic
hypertension
ADR of infliximab
reactivation of TB or HBV, leukemia, lymphoma
ability of methotrexate to do what is why they are useful in crohn’s disease
reduces IL production
which type of laxative “stimulates the natural mechanism”
bulking agents- soluble fiber
MOA of stool softener
anionic surfactant that facilitates mixing of aqueous and fatty substances
role of stool softener
used only for prophylaxis
type of laxative used for acute evacuation
saline osmotic laxatives (magnesium, phosphate)
drug of choice for opioid induced constipation
anthraquinones (senna)
MOA of lubiprostone and linaclotide
increase intraluminal fluid and subsequent bowel movements by increasing secretion of Chloride and bicarbonate ions
m/c and efective OTC agent for diarrhea
loperamide
lomotil =
diphenoxylate + atropine
how does bismuth subsalicylate treat diarrhea
antisecretory
MOA of antispasmodics
induce smooth mm relaxation via anticholinergic effects
