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pharm block 4 > non-HIV > Flashcards

non-HIV Flashcards

1
Q

MOA of the nucleoside analogues

A

compete with endogenous nucleosides for viral DNA polymerase, causing DNA chain termination

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2
Q

ADR of acyclovir

A

renal nephropathy (need hydration)

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3
Q

benefit of valcyclovir

A

prodrug with better bioavailability allows for less frequent dosing than acyclovir

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4
Q

use of penciclovir

A

only used for topical HSV1

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5
Q

famciclovir

A

prodrug of penciclovir, used for HSV and VZV

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6
Q

foscarnet MOA

A

pyrophosphate analogue that reversibly binds to viral DNA polymerase

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7
Q

ADR for foscarnet (4)

A

renal tubular crystallization (hydrate)
seizures
hypocalcemia (binds free Ca)
genital ulceration

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8
Q

MOA of ganciclovir

A

similar to acyclovir, analogue of guanine

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9
Q

when is ganciclovir used?

A

reserved for CMV infections

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10
Q

ADR of ganciclovir

A

bone marrow suppression, renal nephropathy

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11
Q

route of admin for ganciclovir vs valganciclovir

A

ganciclovir- IV

valganciclovir-PO

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12
Q

MOA of cidofovir

A

monophosphate analogue of deoxycytosine

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13
Q

special about cedofovir activation

A

does not require phosphorylation by viral kinase

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14
Q

when is cidofovir used

A

for CMV infections in patients with HIV when galciclovir and foscarnet are ineffective

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15
Q

precautions used with cidofovir

A

give with probenecid and saline infusion to prevent renal tubular secretion/toxicity

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16
Q

goals of HBV therapy

A

suppress HBV replication and slow progression of liver disease- will not eradicate infection, treatment is life long

17
Q

first like agents for HBV (2)

A

tonfovir

entecavir

18
Q

second line agents for HBV

A

interferons

19
Q

ADR of interferons (3)

A

flu-like symptoms
bone marrow suppression
psych disturbances

20
Q

goal of HCV treatment

A

eradication

21
Q

which HCV genotype requires longer treatment

A

genotype 1- 48 weeks

22
Q

first line therapy for HCV genotypes 2,3

A

interferon + ribivirin

23
Q

first line therapy for HCV genotype 1

A

interferon + ribivirin + teleprevir or boceprevir

24
Q

ADR of ribivirin

A

severe hemolytic anemia

25
Q

MOA of sofodbuvir

A

nucleotide analogue RNA pol inhibitor

26
Q

MOA of neuraminidase inhibitors

A

inhibit viral release of A and B

27
Q

MOA of adamantanes

A

inhibit viral uncoating of A

28
Q

alt use for adamatines

A

Parkinson’s disease

29
Q

ADR of adamatines

A

CNS effects

mild to severe

30
Q

MOA of ribivirin

A

interfere with duplication of viral genetic material

pharm block 4 (7 decks)

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