Unit 1.2(ci) - Proteins, Protein structure, ligand binding and conformational change Flashcards
What does amino acid sequence determine?
Protein structure
What are proteins made from?
Polymers of amino acid monomers
what joins amino acids?
Linked by peptide bonds that form polypeptides
What is the primary structure?
The order of amino acids in a protein
What is the secondary structure?
The hydrogen bonding along the backbone of protein strands
What structures are in secondary structure?
Alpha helices
Beta plated sheet
Turns
The conformation of the tertiary structure is decided by
interactions between the R groups
What is Quaternary structure?
Two or more polypeptide chains often linked together by di-sulphide bridges, or other various interactions
What is a prosthetic group?
Additional non-protein structures that give the protein molecule it’s function
Name the 5 bons/interactions that occur between R groups cause further folding of the polypeptide?
Hydrophobic interactions
Ionic bonds
Hydrogen bonds
Van Der Waals
Disulfide bridges
An example of a prosthetic group is
Haem found in red bloods cells in haemoglobin responsible for oxygen carriage
An example of a quaternary structure is
Haemoglobin
What is tertiary structure?
The folding of polypeptide
