Unit 1 - Topic 2 - Proteins - Section C - Protein structure, ligand binding and conformational change - Part III - Reversible binding of phosphate and the control of conformation Flashcards
What does the addition or removal of a phosphate cause and what is it a common form of
Reversible conformational change in proteins. This is a common form of post-translational modification
What catalyses the transfer of a phosphate group to other proteins
Protein kinases
Where is the terminal phosphate of ATP transferred to
Specific R Groups
What does protein phosphatases catalyse
Reverse reaction
What does phosphorylation bring about
The conformational changes, which can affect a protein’s activity
The activity of many cellular proteins such as what is regulated in this way
enzymes and receptors
Some proteins are activated by phosphorylation while others are inhibited how is this done
Adding a phosphate group adds negative charges. Ionic interactions in the unphosphorylated protein can be disrupted and new ones created.