Unit 1 - Topic 2 - Proteins - Section C - Protein structure, ligand binding and conformational change - Part III - Reversible binding of phosphate and the control of conformation Flashcards

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1
Q

What does the addition or removal of a phosphate cause and what is it a common form of

A

Reversible conformational change in proteins. This is a common form of post-translational modification

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2
Q

What catalyses the transfer of a phosphate group to other proteins

A

Protein kinases

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3
Q

Where is the terminal phosphate of ATP transferred to

A

Specific R Groups

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4
Q

What does protein phosphatases catalyse

A

Reverse reaction

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5
Q

What does phosphorylation bring about

A

The conformational changes, which can affect a protein’s activity

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6
Q

The activity of many cellular proteins such as what is regulated in this way

A

enzymes and receptors

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7
Q

Some proteins are activated by phosphorylation while others are inhibited how is this done

A

Adding a phosphate group adds negative charges. Ionic interactions in the unphosphorylated protein can be disrupted and new ones created.

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