UNI 10 LEUKOCTYE DISORDERS, LEUKEMIA + LYMPHOMA

Question 1

3 TYPES OF BLOOD CANCERS=

Answer 1

1. Leukemia = leukocyte
2. lymphoma = lymphocytes
3. myeloma = bone marow + bcs

Question 2

Eosinophilia: (increased)

Answer 2

• Parasitarian infections (helmints)
• Allergies.
• Drugs: side effects.

Question 3

Myeloid ( imature blood cell)

(Granulocytic)

Answer 3

1. Acute: A.M.L.: Acute Myeloblastic Leukemia

2. Chronic: C.M.L: Chronic Myeloid Leukemia

Question 4

Lymphocytic (Agranulocytic)

Answer 4

1. Acute: A.L.L.: Acute Lymphoblastic leukemia

2. Chronic: C.L.L.: Chronic Lymphocytic leukemia

Question 5

difference between acute and chronic?

Answer 5

acute= symtoms in weeks 
chronic = symptoms in years

Question 6

which leukemia is in 80% of chiildren?

Answer 6

ALL

Question 7

in differentiation what does myloid produce and lymphoid produce?

Answer 7

myloid= granulocytes = neutrophils etc
lymphoid = B + T lymphocytes + NK CELLS

Question 8

causes for leukemia?

Answer 8

• hemapoetic mutations = genetic factors, oncogenes

- radiation , virus, drugs

Question 9

what does leukemia produce?

Answer 9

Pancytopenia=

thromobo,leuko+erythropenia = anemia >asthenia

Question 10

where does leukemia disseminate?

Answer 10

spleen + liver + lymph node

Question 11

what is normal number of thrombocytes?

Answer 11

150k-450k

Question 12

adenopathy when?

Answer 12

larger than 1 cm wait 2 months before diagnosis procedures

Question 13

what is a diagnosis procedure for an adenopathy? 2

Answer 13

FNA( FINE NEEDLE ASPIRATION)= syringe obtains cells inbetween serum via aspiration (from sternum)

-local anastheia + biopsy ( from iliac crest)

Question 14

most common reason for adenopathy in old people and young?

Answer 14

young people= virus 
old = malginant neoplasm
• HODGKIN LIMPHOMA
• NON HODGKIN LIMPHOMA
or metastasis

Question 15

Hodgkin lymphoma is what?

Answer 15

“Reed-Sternberg cell“
BINUCELUS
common in ages 10-20 + 50-60

Question 16

LYMPHOMA HAS ASSOCIATION TO WHAT VIRUS?

Answer 16

EBV

Question 17

what are specific clinical manifestations of hodkins lymphoma ? 3

Answer 17

– Lymphadenopathy:
• Head, neck
• Supraclavicular
• Mediastinum

Question 18

what are nonspecific clinical manifestations of hodkins lymphoma ? 4

Answer 18

– Nonspecific constitutional symptoms:
• Fever / feverishness
• Night sweats
• Weight loss
• Pruritus itching

Question 19

staging of hodgkins lymphoma=

Answer 19

stage 1 = metastasis 1 region (Neoplastic)
stage 2 = metastasis in 2 or more places
stage 3 = metastasis in 2/+ places both sides diaphragm
sage 4 = metastasis to 1/+ nonlymphatic organs

Question 20

prognosis of:
1. Myeloid leukemia
2. Lymphocytic leukemia
3. Hodgkin lymphoma
4.  Non- Hodgkin
Lymphoma

Answer 20

1. Myeloid leukemia= medium
2. Lymphocytic leukemia == high 90%
3. Hodgkin lymphoma = high 80%
4. Non- Hodgkin
   Lymphoma = med/low 50%