Type II hypertensitivity

Question 1

abnormal ab directed against a target organ causes destruction of the target cell by complement mediated lysis or by adcc

Answer 1

type II hypersensitivity

Question 2

ab coated target cells can also be destroyed by

Answer 2

ab dependent cellular cytotoxicity

Question 3

autoimmune hemolytic anemia

Answer 3

example of type II

Question 4

abnormal Ab against the basement membrane of the glomeruli

Answer 4

Goodpasture’s syndrome

Question 5

_____ is deposited on the BM of the glomeruli and the lung alveoli

Answer 5

IgG

Question 6

due to abnormal ab to the acetylcholine receptor

Answer 6

myasthenia gravis

Question 7

myasthenia gravis leads to

Answer 7

impaired muscle contraction

Question 8

myasthenia gravis and grave’s disease

Answer 8

anti-receptor dx

Question 9

unregulated overproduction of thyroid hormones of auto-antibody to TSH receptor

Answer 9

Grave’s disease

Question 10

Ag-Ab complexes are trapped in the small vessels of the body. Binding of complement triggers an inflammatory reaction damaging the vessel walls (vasculitis)

Answer 10

immune-complex disease- Type III

Question 11

are trapped in the small vessels of the skin, kidney, joints and other sires

Answer 11

immune complexes

Question 12

are chemotatic for neutrophils

Answer 12

C3a and C5a

Question 13

neutrophils degranulate in vessel wall releasing

Answer 13

lysosomal enzymes

Question 14

what do lysosomal granules do?

Answer 14

damage the vessel wall leading to vasculitis

Question 15

Antigen is DNA and other nuclear components. Antibody is anti-DNA and other antinuclear antibodies (ANA). Complexes are trapped in the small vessels of the skin, kidney and joints

Answer 15

systemic lupus erythematosus (SLE)

Question 16

neutrophils live for

Answer 16

6 hours

Question 17

Circulating anti-streptococcal antibodies combine with streptococcal antigen. Complexes are trapped in the glomeruli

Answer 17

post-streptococcal glomerulonephritis

Question 18

patients treated with serum from an animal such as a horse, will make anti-horse ab

Answer 18

serum sickness

Question 19

localised immune complex disease

Answer 19

arthus reaction

Question 20

arthus reaction

Answer 20

appears when antigen is introduced into an individual who already has ab

Question 21

Farmer’s lung or Bird fancier’s disease

Answer 21

arthus reaction

Question 22

actinomycete organisms are present in mouldy hay

Answer 22

farmer’s lung

Question 23

repeated inhalation of actinomycete organisms stimulate systemic

Answer 23

IgG ab production

Question 24

what happens in farmer’s lung that will make it a type III and type IV

Answer 24

infiltration by T-cells with cytokine production and further inflammation (type IV)