complement system

Question 1

a series of proteins working in a cascading manner

Answer 1

complement

Question 2

activated by Ag-Ab (antigen-antibody) Complexes

Answer 2

Classical complement system

Question 3

C1q, C1r and C1s bind to the complement binding site on the

Answer 3

Fc portion of the antibody portion

Question 4

Activated C1

Answer 4

C1q, Cir and Cis

Question 5

C1 will break C4 into

Answer 5

C4a and C4b

Question 6

_____________sticks to the activated C1 and this complex is called ____________

Answer 6

C4b and become s C14b

Question 7

C14b splits C2

Answer 7

C2a and c2b

Question 8

order of C

Answer 8

1, 4, 2, 3

Question 9

C6, C7, C8, and C9 bind to C5b forming the

Answer 9

Membrane Attack Complex (MAC)

Question 10

punch holes into the membrane

Answer 10

MAC

Question 11

Coating of organism with antibody and C3b so that they are more easily phagocytosed by neutrophils and macrophages

Answer 11

opsonization

Question 12

nuetrophils alone the phagocytic activity is low but when you add antibody

Answer 12

the activity increases and the phagocytosis becomes efficient

Question 13

C3a and C5a

Answer 13

chemotaxis and anaphylatoxin production

Question 14

phagocytic cells are attracted to the site of the antigen

Answer 14

Chemotaxis

Question 15

degranulate mast cells and basophils

Answer 15

C3a and C5a

Question 16

coated with specific antibody- C8 and C9

Answer 16

lysis of organisms

Question 17

C1-INH

Answer 17

inhibits the complement system

Question 18

activated by bacterial or viral products like LPS

Answer 18

alternative complement pathway

Question 19

inhibitors of the alternative pathway and regulate the activation of the system

Answer 19

Factor H and Factor I

Question 20

alternative pathway splits C3 into C3a and C3b and continuous the complement cascade

Answer 20

C3bBbP

Question 21

Generate C3bBbP (alternative complement)

Answer 21

Factor B, Factor D and Properdin

Question 22

activated by organisms with mannose on their surface

Answer 22

Lectin pathway

Question 23

Proteins that activate Lectin Pathway

Answer 23

Organisms that express mannose in their surface. Most important proteins:

1. MBL (mannose binding protein_
2. MASP1
3. MASP2

Question 24

associated with SLE

Answer 24

Absence of C1q, C2 or C4

Question 25

severe recurrent bacterial infections

Answer 25

Absence of C3

Question 26

bacterial infections

Answer 26

Absence C5

Question 27

overwhelming Neisserial infections (N.meningitidis and N.gonorrhea)

Answer 27

Absence C6, C7, or C8

Question 28

recurrent bacterial infections

Answer 28

absence of alternative pathway components

Question 29

infection in childhood

Answer 29

Absence of Lectin pathway proteins

Question 30

Hereditary angioedema

Answer 30

Absence of C1-INH

Question 31

rare autosomal dominant genetic disorder resulting from an inherited deficiency or dysfunction of the C1 inhibitor

Answer 31

Hereditary angioedema

Question 32

Only complement pathway that is part of adaptive immunity

Answer 32

Classical complement pathway

Question 33

Neisserial infections (2)

Answer 33

Meningitis, Gonorrea

Question 34

Activates phagocytosis

Answer 34

C3b

Question 35

Activates mast cells

Answer 35

C3a C5a

Question 36

Recruits neutrophils

Answer 36

C3a, C5a

Question 37

____ receptor in macrophages binds to antibody Ig__

Answer 37

Fc-gamma receptor in macrophages binds to antibody IgG

Question 38

Ig_ and Ig_ actviate complement

Answer 38

IgG and IgM