complement system Flashcards

exam 4

1
Q

a series of proteins working in a cascading manner

A

complement

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2
Q

activated by Ag-Ab (antigen-antibody) Complexes

A

Classical complement system

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3
Q

C1q, C1r and C1s bind to the complement binding site on the

A

Fc portion of the antibody portion

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4
Q

Activated C1

A

C1q, Cir and Cis

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5
Q

C1 will break C4 into

A

C4a and C4b

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6
Q

_____________sticks to the activated C1 and this complex is called ____________

A

C4b and become s C14b

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7
Q

C14b splits C2

A

C2a and c2b

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8
Q

order of C

A

1, 4, 2, 3

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9
Q

C6, C7, C8, and C9 bind to C5b forming the

A

Membrane Attack Complex (MAC)

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10
Q

punch holes into the membrane

A

MAC

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11
Q

Coating of organism with antibody and C3b so that they are more easily phagocytosed by neutrophils and macrophages

A

opsonization

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12
Q

nuetrophils alone the phagocytic activity is low but when you add antibody

A

the activity increases and the phagocytosis becomes efficient

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13
Q

C3a and C5a

A

chemotaxis and anaphylatoxin production

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14
Q

phagocytic cells are attracted to the site of the antigen

A

Chemotaxis

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15
Q

degranulate mast cells and basophils

A

C3a and C5a

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16
Q

coated with specific antibody- C8 and C9

A

lysis of organisms

17
Q

C1-INH

A

inhibits the complement system

18
Q

activated by bacterial or viral products like LPS

A

alternative complement pathway

19
Q

inhibitors of the alternative pathway and regulate the activation of the system

A

Factor H and Factor I

20
Q

alternative pathway splits C3 into C3a and C3b and continuous the complement cascade

21
Q

Generate C3bBbP (alternative complement)

A

Factor B, Factor D and Properdin

22
Q

activated by organisms with mannose on their surface

A

Lectin pathway

23
Q

Proteins that activate Lectin Pathway

A

Organisms that express mannose in their surface. Most important proteins:

  1. MBL (mannose binding protein_
  2. MASP1
  3. MASP2
24
Q

associated with SLE

A

Absence of C1q, C2 or C4

25
severe recurrent bacterial infections
Absence of C3
26
bacterial infections
Absence C5
27
overwhelming Neisserial infections (N.meningitidis and N.gonorrhea)
Absence C6, C7, or C8
28
recurrent bacterial infections
absence of alternative pathway components
29
infection in childhood
Absence of Lectin pathway proteins
30
Hereditary angioedema
Absence of C1-INH
31
rare autosomal dominant genetic disorder resulting from an inherited deficiency or dysfunction of the C1 inhibitor
Hereditary angioedema
32
Only complement pathway that is part of adaptive immunity
Classical complement pathway
33
Neisserial infections (2)
Meningitis, Gonorrea
34
Activates phagocytosis
C3b
35
Activates mast cells
C3a C5a
36
Recruits neutrophils
C3a, C5a
37
____ receptor in macrophages binds to antibody Ig__
Fc-gamma receptor in macrophages binds to antibody IgG
38
Ig_ and Ig_ actviate complement
IgG and IgM