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Immunology 4 > rEVIEW > Flashcards

rEVIEW Flashcards

1
Q

Opsonization requires

A

C3b

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2
Q

Chemotaxis requires

A

C3a and C5a

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3
Q

Anaphylatoxin requires

A

C3a and C5a

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4
Q

Cytolytic activity requires the MAC components

A

(C5b-C9)

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5
Q

C1-INH

A

angioedema

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6
Q 
IL-1
TNF
IL-6
IL-12
Chemokines
IL-10 - Inhibitory
A

From Antigen presenting cells

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7
Q

IFN-gamma

IL-2

A

Th1 cells

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8
Q

IL-4
IL-5
IL-13

A

Th2 cells

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9
Q

IL-17

A

CD17

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10
Q

IL-10

TGF-beta

A

From Treg cells

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11
Q

Expressed only on APC and binds to CD4+

A

MHCII

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12
Q

expressed on all nucleated cells nd binds CD8+ cells

A

MHCI

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13
Q

due to pre-formed antibodies in the recipient against the donor. Takes minutes or hours

A

Hyperacute rejection

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14
Q

due mainly to CMI (both CD4 and CD8 cells) against donor MHC molecules. Also some antibody attack. Takes 10-14 days

A

Acute Rejection

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15
Q

due to CMI and antibody attack

A

Chronic rejection

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16
Q

CD4+ T cells in the graft are activated by allogeneic molecules and produces a

A

cytokine storm

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17
Q

a reaction of donor T-cells against recipient MHC

A

GVH

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18
Q

CD19, CD20, MHC Class I, MHC Class ll and Kappa light chains

A

B-cell lymphoma

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19
Q

2-5 days reaction of a rejection

A

sensitized–> T-cells activated but no antibodies present

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20
Q

. Tumor cells can be destroyed by ____ T-cells that recognize tumor antigen presented by MHC Class l

A

CD8+

21
Q

releases granzymes and perforins and the Fas-Fas L interaction

A

T cell

22
Q

CD8 cells are the principal line of defense against:

4

A
  1. virus infected cells
  2. intracellular bacteria
  3. fungi
  4. tumors
23
Q

large, granular lymphocytes

A

natural killer cells

24
Q

recognize abnormal cells that have lost MHC I

A

NK cells

25
Q

how do NK cells destroy target cells

A

with granzymes and perforins

26
Q

occurs 4-8 hours later and is due to eosinophils, neutrophils, T-cells and mononuclear cells, migrating into the area.

A

Late phase of the acute allergic reaction

27
Q

A speleologist (person who explores caves) is attacked and bitten by a bat. Fearing that the animal may be rabid his physician injects the man with a dose of horse anti-rabies serum. Within 10 minutes he complains of generalized itching, and urticarial wheals (hives) appear on his skin. The most likely cause of this is:

A)          Circulating immune complex deposition
B)	An Arthus reaction
C)	Direct effect of bat saliva on mast cells
D)	A type II cytotoxic reaction
E)          IgE-mediated allergic reaction
A

E) IgE-mediated allergic reaction

28
Q
  • antibodies to red cell membranes
A

Autoimmune hemolytic anemia

29
Q
  • antibodies to platelet membrane proteins
A

Autoimmune thrombocytopenia

30
Q

antibodies to proteins in glomerular basement membrane and alveolar basement membrane

A

Goodpasture’s syndrome

31
Q

streptococcal antibody cross reacts with a myocardial antigen

A

Rheumatic fever

32
Q

-antibody to acetylcholine receptor

A

Myasthenia gravis

33
Q

antibody to the TSH receptor

A

Graves’ Disease

34
Q

SLE

A

immune complex disease

35
Q

Bird fancier

A

Arthus rxn./ localised immune complex and she also has some T-cell infiltration showing Type IV

36
Q

macrophages, dendritic cells, CD4+ and CD8+ T-cells.

A

Type IV

37
Q

Patch skin test

A

Type IV

38
Q

RAST test

A

Type I

39
Q

candida

A

Type IV

40
Q 
Dan receives a bone-marrow transplant from an HLA matched brother.  This is an example of an
Autograft
Syngraft
Xenograft
Allograft
A

Allograft

41
Q

Because although the donor and recipient are matched at the MHC, the donor T-cells must be recognizing some foreign antigen in the recipient.

A

GVH

42
Q

What is the treatment of GVH

A

Immunosuppression with drugs such as cyclosporine

43
Q

How can we prevent GVH

A

Try to remove all the T-cells from the donor bone marrow preparation.

44
Q

Physical exam is remarkable for dry, red patches of skin (eczema) and multiple petechiae (tiny hemorrhagic spots). Lab findings include thrombocytopenia (low platelet count) and reduced IgM levels.

A

Wiskott-Aldridge Syndrome

45
Q

Which of the following patients would not have increased susceptibility to infection with Mycobacterium tuberculosis?

A) Patient with a mutation of the IL-2 receptor
B) Patient with a mutation of the IL-12 receptor
C) Patient with a mutation of the RAG-1 gene
D) Patient with a mutation of the CD 28 gene
E) Patient with a mutation of the Btk gene

A

E) Patient with a mutation of the Btk gene

46
Q

Mutations of the Btk gene are responsible

A

X-linked agammaglobulinemia.

47
Q

X-linked agammaglobulinemia has normal T-cell function

A

YEP

48
Q

CD28 competes with

A

CTL4, an inhibitory receptor

49
Q

T cell regulation

A
  • CTL4

- PD1

Immunology 4 (9 decks)

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