Type II Diabetes Pharmacology Flashcards
How do sulfonylureas cause insulin release?
By binding to the SUR1 protein to close the channel and cause depolarisation
How do GLP-1 agonists cause insulin secretion?
By binding to GLP-1 receptors to increase intracellular cAMP concentration
How do gliptins work?
Competitively inhibit DPP-4 prolonging incretin action
What is alpha-glucosidase?
Brush border enzyme that breaks down starch and disaccharides to absorbable glucose
How do alpha-glucosidase inhibitors reduce blood glucose?
As they delay absorption of glucose
How does metformin work?
It reduces hepatic gluconeogenesis
How do TZDs work?
Agonises the PPAR gamma transcription factor which promotes insulin signalling
How do SGLT2 inhibitors work?
Selectively block glucose reabsorption by SGLT2 to cause glucosuria
