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Endocrine > Type 3 and 4 Diabetes > Flashcards

Type 3 and 4 Diabetes Flashcards

1
Q

What is Type 3 Diabetes?

A

Gestational diabetes

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2
Q

Describe gestational diabetes

A

Insulin resistance occuring during pregnancy which usually resolves upon giving birth

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3
Q

What problems can occur from gestational diabetes

A

Development of T2DM later in life

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4
Q

What should sufferers of gestational diabetes receive for the rest of their lives?

A

Check up every 3 years for diabetes

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5
Q

What is type 4 diabetes?

A

Anything other than T1/2/3 that can cause insulin production or signalling problems.

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6
Q

What are the 6 broad categories of T4DM?

A 
Mature Onset Diabetes of the Young
Drug induced
Neonatal
Pancreatic diseases
Endocrine disorders
Genetic diseases
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7
Q

Give some examples of genetic diseases that can cause diabetes?

A 
CF
Myotonic dystrophy
Turner's Syndrome
Wolfram Syndrome (DIDMOAD)- Rare
Bardet-Biedl Syndrome
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8
Q

Give some examples of drugs that can cause diabetes

A

Steroids
B-blockers
Diuretics
Some cancer therapies

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9
Q

Give some examples of endocrine disorders that can cause diabetes

A

Acromegaly

Cushing’s syndrome

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10
Q

Give some examples of pancreatic disorders that can cause diabetes

A

CF
Pancreatitis
Haemochromatosis

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11
Q

What is neonatal diabetes?

A

Diabetes that develops with in 1st 3 months of life

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12
Q

What are the two categories of neonatal diabetes?

A

Transient neonatal diabetes

Permanent neonatal diabetes

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13
Q

When does transient neonatal diabetes present?

A

1st week of life

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14
Q

How long does transient neonatal diabetes take to resolve?

A

~12 weeks

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15
Q

How do you treat transient neonatal diabetes?

A

Insulin until it resolves

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16
Q

When does permanent neonatal diabetes present?

A

0-6 weeks old

17
Q

How do you treat permanent neonatal diabetes?

A

Life long insulin

18
Q

What is Mature Onset Diabetes of the Young (MODY)?

A

Hereditary form of diabetes caused by inappropriate insulin production or release.

19
Q

What are the two main mechanism for MODY?

A

Glucokinase mutations

Transcription Factor HNF-1alpha mutations

20
Q

How do glucokinase mutations cause MODY?

A

Impair glucose sensing therefor require higher conc for insulin secretion. Get stable hyperglycemia

21
Q

When does glucokinase linked MODY present?

22
Q

How do you treat glucokinase linked MODY?

A

Diet control

23
Q

How do transcription Factor HNF-1alpha mutations cause MODY?

A

Causes malfunction of Kir6 therefore no depol

24
Q

How does Transcription Factor HNF-1alpha mutations MODY present?

A

Progressive hyperglycemia in adolescents

25
Q

How do you treat Transcription Factor HNF-1alpha mutations MODY?

A

1/3 Diet control
1/3 Insulin
1/3 SUs

26
Q

How do you diagnose MODY?

A

Genetic screening
Usually <25YO
C-peptide positive
GAD negative

Endocrine (23 decks)

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