Obesity Flashcards

1
Q

What three complications can obesity cause in the head?

A

Intracranial hypertension
Stroke
Cataracts

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2
Q

What two complications can obesity cause in the thorax?

A

Pulmonary disease

CHD

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3
Q

What four complications can obesity cause in the abdomen?

A

Pancreatitis
NAFLD
Gallbladder disease
Gynecological abnormalities

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4
Q

What two complications can obesity cause in the lower limb?

A

Osteoarthritis

Venous stasis

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5
Q

What five systemic complications can obesity cause?

A
Gout
Infection
DIabetes
Dyslipidemia
Hypertension
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6
Q

What seven cancers can obesity increase your risk of?

A
Breast
Uterus 
Kidney
Colon
Oesophageal
Pancreatic
Gallbladder
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7
Q

What are the two main measures of obesity?

A

BMI

Waist circumference

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8
Q

What are the cut offs for BMI categories in whites?

A
UW <18.5
Healthy 18.5-24.9
Overweight 25-29.9
Obese 30-34.9
Morbidly obese >35
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9
Q

What are the cut offs for BMI in Asians, Indonesians etc?

A

UW <18.5
Healthy 18.5-23
Overweight 23-27.5
Obese >27.5

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10
Q

What are the waist circumference categories and their cut offs in white males?

A

Normal <90cm
Overweight 90-94cm
Obese >94cm

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11
Q

What are the waist circumference categories and their cut offs in females?

A

Normal <80cm
Overweight 80-88cm
Obese >88cm

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12
Q

What are the waist circumference categories and their cut offs in Asian males?

A

Normal <90cm

Overweight >90

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13
Q

What are some risk factors for developing obesity?

A
Deprivation
Child of obese
Rapid weight gainers
Post obese
Smoking quitters
Pregnant
Physical inactivity 
Ethnic groups
Genetics
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14
Q

What are the three main drivers for obesity?

A

Increased availability to cheap energy dense food
Increased food marketing
Decreased physical activity

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15
Q

What are the best ways to prevent obesity?

A

Decreased energy intake
Decrease sedentary behaviours
Increased physical activity

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16
Q

What are the three policy targets for changing obesity?

A

Consumer environment
Systems
Behaviour change

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17
Q

Give examples of consumer environment policy targets

A

Make healthier food cheaper

Provide info on healthy foods and exercise

18
Q

Give examples of system policy targets

A

Make it easier to distribute healthy foods
Change marketing
Make physical activity easier to access

19
Q

Give examples of Behaviour change policy targets

A

Educate people on healthy options
Teach to cook
Teach sports

20
Q

What peptides of interest can adipocytes secrete?

A
Leptin
Adiponectin
CRP
TNF alpha
IL-6
Oestrogen
Cortisol
21
Q

What happens when an adipocyte swells too much?

A

It becomes inflamed leading to insulin insensitivity.

22
Q

What are four ways we can treat obesity?

A

Diet control
Exercise
Drugs
Surgery

23
Q

Why is diet control favoured in the morbidly obese?

A

Due to lack of capacity to exercise.

24
Q

What is the only drug approved for obesity control in the UK?

25
How does orlistat work?
Lipase inhibitor thus preventing lipid absorption from the diet.
26
What is surgery for the treatment of obesity called?
Bariatric surgery
27
What is bariatric surgery?
Surgery for the treatment of obesity.
28
What are the three most common forms of bariatric surgery in the UK?
Gastric band Gastric bypass Vertical Sleeve Gastrectomy
29
What is a gastric band?
Band placed round the stomach to make it smaller therefore decrease portion size
30
What is a Vertical Sleeve Gastrectomy?
Remove fundus of stomach to form sleeve thus reducing stomach volume.
31
What is a gastric bypass?
Connection of small part of stomach to Jejunum leading to decreased volume and malabsorption.
32
What can make it hard to maintain weight loss?
RMR falls as weight is loss therefore need to do more work to keep it off.
33
Why does RMR fall as weight is lost?
Adaptive thermogenesis
34
What is adaptive thermogenesis?
When lots of weight is loss body sees this as a threat therefore acts to prevent further weight loss.
35
What two hormones report fat levels to the brain?
Insulin | Leptin
36
What does leptin do in the brain?
Stimulates decreased food intake and increases energy burning.
37
What do leptin KO mouse models show?
Obesity
38
What happens to leptin levels in the obese state?
Increase but brain sensitivity decreases.
39
Can injections of leptin help prevent obesity?
No due to resistance.
40
What are some of the side effects of orlistat?
Cramping Diarrhoea Loss of fat soluble vitamins
41
What receptor is being investigated with links to obesity?
Delta9-THC receptor
42
Why is the Delta9-THC receptor being investigated with respect to diabetes?
Because KO show decreased appetite and are lean