Type 2: Thiazolidinediones - eg pioglitazone

Question 1

What is the MHRA warning

Answer 1

• Associated with heart failure (increased risk when given with insulin) MHRA warning

Risk of bladder cancer

Question 2

MOA

Answer 2

Works by reducing peripheral resistance

Question 3

Warning signs

Answer 3

1. . Bladder cancer
2. . Hepatic toxicity
3. . Heart failure – worsened when taken with insulin

Question 4

Common side effects

Answer 4

Bone fracture (osteoporosis) , weight gain, increase risk of infection, visual impairment, numbness

Only continue if HBA1C is reduced by 0.5% with 6 months of treatment.

Question 5

Monitoring

Answer 5

Monitor liver function and advice patients to report signs of liver toxicity