Male sex hormones Flashcards

1
Q

What are androgens

A

They cause masculinity and are important in males

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2
Q

When are androgens used

A

In castrated adults and in those who are hypogonadal

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3
Q

What is hypogonadal

A

Hypogonadism is a medical term for decreased functional activity of the gonads.

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4
Q

What do androgens do in normal makes?

A

Inhibit spermatogenesis because they decrease another hormone called FSH

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5
Q

What did androgens lead to the development of

A

Anabolic steroids

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6
Q

What are examples of androgens

A

Testosterone

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7
Q

What are some anti-androgens

A

Cyproterone acetate (treatment of severe hypersexuality in males

Finasteride and Dutasteride

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8
Q

What is the use of finasteride and dutasteride?

A

Alternatives to alpha blockers (-osin.” These medications include alfuzosin, doxazosin, terazosin, tamsulosin, and prazosin) in enlarged prostrates (finasteride 5mg used WITH doxazosin too)

Finasteride 1mg is used in male pattern baldness

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9
Q

What are some side effects of finasteride and dutasteride?

A

Impotence

Decreased libido

Ejaculation disorders

Breast tenderness and enlargement

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10
Q

What does finasteride do?

A

Inhibitor of the enzyme 5 alpha reductase

This enzyme normally metabolises testosterone into the more potent androgen dihydrotestosterone

Taking finasteride reduces this significantly

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11
Q

What is the MHRA warning of finasteride

A

MHRA advice for finasteride

Reports of suicidal thoughts and depression in men taking it for male pattern baldness

Breast cancer in males can also happen

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