Male sex hormones Flashcards
What are androgens
They cause masculinity and are important in males
When are androgens used
In castrated adults and in those who are hypogonadal
What is hypogonadal
Hypogonadism is a medical term for decreased functional activity of the gonads.
What do androgens do in normal makes?
Inhibit spermatogenesis because they decrease another hormone called FSH
What did androgens lead to the development of
Anabolic steroids
What are examples of androgens
Testosterone
What are some anti-androgens
Cyproterone acetate (treatment of severe hypersexuality in males
Finasteride and Dutasteride
What is the use of finasteride and dutasteride?
Alternatives to alpha blockers (-osin.” These medications include alfuzosin, doxazosin, terazosin, tamsulosin, and prazosin) in enlarged prostrates (finasteride 5mg used WITH doxazosin too)
Finasteride 1mg is used in male pattern baldness
What are some side effects of finasteride and dutasteride?
Impotence
Decreased libido
Ejaculation disorders
Breast tenderness and enlargement
What does finasteride do?
Inhibitor of the enzyme 5 alpha reductase
This enzyme normally metabolises testosterone into the more potent androgen dihydrotestosterone
Taking finasteride reduces this significantly
What is the MHRA warning of finasteride
MHRA advice for finasteride
Reports of suicidal thoughts and depression in men taking it for male pattern baldness
Breast cancer in males can also happen