Type 2: Dipeptidylpeptidase-4 inhibitors (Gliptins) Flashcards
1
Q
What are some examples
A
alogliptin, linagliptin, sitagliptin, saxagliptin, vidagliptin
2
Q
Contraindication
A
DKA
3
Q
Side effects
A
GI and skin reactions
Discontinue if symptoms of acute pancreatitis (e.g. persistent abdominal pain)
4
Q
Mechanism of action
A
Inhibits dipeptidyl peptidase - 4 to increase insulin secretion and lower glucagon secretion
5
Q
Do they cause weight gain
A
No
6
Q
How should they be taken
A
With or after food
7
Q
When to reduce sitagliptin dose
A
Dose reduction for sitagliptin in renal impairment
● Dose reduction to 50 mg once daily if eGFR 30–45 mL/minute/1.73 m2.
8
Q
Which one is preferred in renal failure
A
Linagliptin
