Type 2: Sulfonylureas – IDES

Question 1

What are some examples of these

Answer 1

Gliclazide, glimepiride, glipizide, tolbutmamide

Question 2

Can they cause hypoglycaemia?

Answer 2

Yes

Question 3

Can they cause weight gain?

Answer 3

Yes

Question 4

Can they be used in pregnancy?

Answer 4

No

Question 5

When are they given

Answer 5

When metformin is contraindicated

Question 6

When should it be avoided?

Answer 6

Before surgery - change to insulin

Question 7

Side effects

Answer 7

GI (n&v, diarrhoea and constipation), hepatic impairment, allergic skin reactions in first 6-8 weeks, jaundice

Question 8

Which patients should you use this in caution with

Answer 8

Caution in elderly pts with G6PD deficiency

Question 9

Mechanism of action

Answer 9

Augment insulin secretion and consequently, only effective when some residual pancreatic beta cell activity is present

Question 10

Give examples of long and short acting

Answer 10

Short – gliclazide

Long - Gliblenclamide

Question 11

Interactions of the -ides

Answer 11

NSAIDs, ACE inhibitors, st john wort