Type 2 Hypersensitivity

Question 1

Type 2 Hypersensitivity

Answer 1

Antibody Mediated cytotoxicity
* Mediated by antibodies that recognise antigens on a cell surface or space between cells
* Activates classical complement pathway

Question 2

Which antibody is involved in Type 2?

Answer 2

IgG

Question 3

How is type 2 different to type 1

Answer 3

Involves type IgG not IgE
Antibodies are circulating in blood, not bound to mast cells

Question 4

Intrinsic antigens

Answer 4

Part of cell membrane

Question 5

Extrinsic antigens

Answer 5

Introduced from outside

Question 6

What does classical complement cascade cause?

Answer 6

Destruction/dysfunction of cells by phagocytosis or cell lysis

Question 7

Intrinsic vs extrinsic

Answer 7

Antibodies attacking an extrinsic pathogen is okay (e.g. drug reaction)
Antibodies attacking an intrinsic pathogen is not okay (e.g. hormone receptors)

Question 8

Intrinsic Antigen groups

Answer 8

○ Protein antigens on cell membranes
Can lead to autoimmune anaemia
○ Antigens in matrix between cells
○ Receptor antigens or cells
Mainly hormone receptors

Question 9

Myasthenia Gravis

Answer 9

Neuromuscular disorder
Attack of intrinsic antigens (ACh)
Results in skeletal muscle weakness