Adverse Consequences of Vaccinations Flashcards
Aim of safety of veterinary vaccines
To reduce risk of adverse effects
Methods of making veterinary vaccines safer
Pre-licensing testing
Marketing authorisation licence
post-licensing testing
Pre-licensing testing
Testing on health laboratory animals
Improves safety
Tests efficacy
Done under strict conditions
How is efficacy studied
Under strict laboratory conditions in healthy animals
How is effectivity studied?
How well a vaccine works in various situations
Marketing authorisation licence
European Medicines Agency
Veterinary Medicines Directorate
Post-licensing testing
Batch-release safety tests
* Checking a group of immunised animals have the same level of immune response to those in the trials
Adverse events
Vaccine-induced effect
Vaccine-potentiated effect
Programatic error
Coincident effects
Vaccine-induced effect
The aim of a vaccine is to induce an immune response
* Will cause inflammation
* Effect directly caused by vaccine
Vaccine-potentiated effect
- Underlying conditions exacerbated by vaccination
Programmatic error
If you administer incorrectly
Coincident effect
Can’t say if it was to do with vaccine
Difficult to differentiate whether or not an animal got sick
Examples of adverse events
Heat, swelling, redness
Lethargy
Appetite loss
Fever can cause pregnancy loss
Allergic reactiona
Injection site sarcoma
Type 1 hypersensitivity
Related to allergies
IgE mediated allergic reaction
Occurs within a few minutes
Type 2
Involves IgG and complement
Antibody mediated cytotoxicity
