Type 2 Diabetes Flashcards

1
Q

glucose sources

A

intestinal absorption, glycogenolysis, gluconeogenesis

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2
Q

In fasting state, glucagon levels increase/decrease

A

increase

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3
Q

Glucagon

A

stimulates glycogenolysis and gluconeogenesis

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4
Q

In fasting state, insulin levels increase/decrease

A

decrease

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5
Q

During eating, insulin levels increase/decrease

A

increase

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6
Q

Which tissues absorb glucose due to insulin?

A

muscle, liver, adipose

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7
Q

Insulin resistance

A

reduced response to circulating insulin

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8
Q

Insulin resistance hyperglycemia

A

liver, muscle, adipose glucose intake is low and liver glucose output is high –> hyperglycemia

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9
Q

There is a _______ relationship between insulin secretion and insulin resistance

A

hyperbolic

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10
Q

As one gains weight and becomes obese, it is possible to maintain glucose balance if ____

A

pancreas increases insulin output –> this ability drops off over time

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11
Q

Prediabetes

A

impaired glucose tolerance, impaired fasting glucose

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12
Q

Why do post-prandial sugars rise first after some years of prediabetes?

A

as ability to ensure high level of insulin secretion tapers off and starts declining, the body has a more difficult time coping with high carbohydrate load vs. simply shutting off liver glucose production –> post prandial sugars rise before fasting glucose

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13
Q

First indicator of diabetes

A

rise in insulin

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14
Q

By the time of diagnosis, ____% of beta cells are long gone.

A

50%

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15
Q

normal fasting glucose

A

100 = more cardiovascular risk)

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16
Q

2hr plasma glucose after 75gm CHO load

A

<140 mg/dL

17
Q

100<200 mg/dL

A

prediabetes

18
Q

T/F most people with prediabetes develop type 2 diabetes within 10 years

19
Q

First phase of insulin secretion

A

task is to take care of just-consumed CHO and shut down glucose production –> insulin in beta cell granules

20
Q

Second phase of insulin secretion

A

task is to maintain blood sugar that has been absorbed prior –> gradual increase in insulin

21
Q

___ phase of insulin secretion is missing in T2D.

A

first phase

22
Q

Deposition of ____ disrupts alpha/beta cell communication.

A

amyloid –> inappropriately high glucagon secretion stimulates liver production of glucose and therefore hyperglycemia

23
Q

intestinal hormones that are released in response to food ingestion

24
Q

Incretins

A

glucagon like peptide 1 (GLP1) and gastric inhibitory polypeptide (GIP) stimulate insulin secretion in the presence of glucose –> account for 60-70% of postprandial insulin response

25
Incretin response
difference between insulin load from oral glucose and from iv glucose
26
T/F response to GLP1 is preserved in diabetes
T
27
GLP1 effect on glucagon
reduces glucagon -->reduces hepatic glucose output
28
GLP1 effect on stomach
slows gastric emptying --> attenuates post-prandial hyperglycemia
29
GLP1 effect on CNS
promotes satiety and reduction of appetite
30
4 main defects in Type 2 Diabetes
decreased insulin action, decreased insulin secretion, inadequate glucagon suppression and excess hepatic glucose production, defective incretin response
31
Risk factors for T2D
obesity, race, metabolic factors, lifestyle, genetics, gestational diabetes, intrauterine
32
Nonspecific clinical presentation of T2D
fatigue, blurry vision, poor wound healing, dry mouth/skin, recurrent infections (candadiasis)
33
Classic symptoms of T2D
polyuria/dipsia/phagia, unexplained weightloss
34
Physical exam findings of T2D
obesity, skin changes, candidal infection, fundoscopic/neurologic (decreased sensation)/feet changes (ulcers)
35
skin changes in T2D
acanthosis nigricans, skin tags, furuncles and carbuncles
36
Diagnostic criteria for T2D
fasting glucose>126 on two separate occasions or random glucose>200 with classic sx or 2hr glucose test >200 or hba1c>6.5%
37
_____ reflects average plasma glucose level over past 2-3 months
hemoglobin a1c
38
After gastric bypass levels of _____ are highg
GLP1