Endocrine and Aging

Question 1

Menopause

Answer 1

E2 declines –> happens when run out of eggs

Question 2

Andropause

Answer 2

T declines

Question 3

Adrenopause

Answer 3

DHEA declines but no change in cortisol or ACTH

Question 4

Somatopause

Answer 4

GH/IGF1 declines

Question 5

Estrogen/progesterone combined tx after menopause increases/decreases: breast cancer, stroke, CAD risks

Answer 5

increases relative risk of all of them

Question 6

ERT increases/decreases: CHD, CA, stokre, VTE, hip fx

Answer 6

decreases risk –> but globally no risk or benefit

Question 7

T/F ERT can prevent dementia

Answer 7

F –> no difference in global cognitive function

Question 8

T/F low dose ERT during peri/menopause is relatively safe

Answer 8

T –> but not after long period without estrogen (e.g. 70 year old woman)

Question 9

bioidentical hormones

Answer 9

compounds that have the same structure as those in human body –> promoted as safer and more effective alternatives to traditional hormone therapies

Question 10

Increase or decrease with age in men? LH amplitude, frequency, basal

Answer 10

decrease amplitude, increased frequency, increased basal

Question 11

Is there a benefit to DHEA replacement?

Answer 11

no real evidence for benefits or risks

Question 12

Nocturnal minimal cortisol in older people is higher/lower

Answer 12

higher –> overall higher exposure to cortisol –> muscle loss, adiposity, less REM

Question 13

T/f older people are more likely to have an abnormal 2 hour glucose on GTT

Answer 13

T

Question 14

T/F evidence demonstrates subclinical hypothyroidism increases risk of CVD

Answer 14

F

Question 15

There are age associated increase/decrease in nocturnal cortisol and glucose intolerance

Answer 15

increase

Question 16

T/F harder to recognize hyper or hypothyroidism in older people

Answer 16

T –> non classical presentation