Pediatric Endocrinology Flashcards
T/F menarche marks the beginning of the reduction in girls’ growth rate
T
Early indicator of constitutional delay
delayed dental development
GH
Pituitary GH –> Liver IGF1 –> metabolic and bone effects –> used in screening
T/F Most SGA catch up in weight/length
T –> 10-15% of small for gestational age do not catch up by age 2
Endocrine disorders that lead to growth changes
hypothyroidism, cortisol excess, GH deficiency
Bone Age Xray
Width of epiphyses spans full width of finger and are beginning to fuse –> delayed bone age = late bloomer or disease process //normal bone age but short stature = genetically short stature
T/F Random GH evaluation is useful
F –> GH is pulsatile, mainly at night, and difficult to measure
Screening tests for growth hormone
IGF1 and IGFBP3
T/F Low IGF1 can be seen in malnutrition
T
T/F turner’s syndrome patients have close to normal intelligence
T
Elevated ESR may indicate:
Crohn’s disease
T/F can tell difference between girls/boys hormonalyl at puberty
T
T/F can tell difference between girls/boys hormonally at childhood
F –> GnRH suppression
What hormone leads to bone fusion?
estrogen
Breast enlargement in neonates
due to maternal estrogen –> usually subsides
T/F both androgen and estrogen play a role in growth surge
T –> androgens are converted to estrogen for bone growth so too much androgens will lead to growth surge
DHEA-S is specific to what organ?
adrenal –> high DHEAS early might suggest early awakening of adrenal
elevated 17 hydroxy progesterone might suggest:
CAH
Below age of ___ in a boy with testicular enlargement is early.
9 (also concerned about no testicular development until after 14)
Central causes of precocious puberty
idiopathic, CNS pathology, hamartoma
Peripheral causes of precocious puberty
ovarian cysts, McCune-Albright, Exogenous
McCune-Albright
bone, skin pigmentation, precocious puberty
most common organic central cause of precious puberty
hamartoma –> in pineal region
Tx of precocious puberty
Lupron, Histrelin Implant
Histrelin Implant/lupron MOA
continuous GnRH –> pituitary shuts down LH/FSH release –> delays puberty
Tanner 1 means ___
no development of breasts/pubic hair
Onset of puberty is related to tanner ___
stage 4 –> raised areola
How many babies born with congenital hypothyroidism
1/4000 –> preventable mental retardation
