Macrovascular complications

Question 1

T/F Diabetics are less likely to have asymptomatic cardiovascular disease than non-diabetics.

Answer 1

F

Question 2

T/F Diabetics with cvd tend to have worse clinical outcomes

Answer 2

T

Question 3

Most important risk factor for macrovascular disease in t1d

Answer 3

duration of diabetes

Question 4

Atherosclerosis development

Answer 4

hyperglycemia + hyperinsulinemia, + small, dense LDL + low DL + high TG + hypertension + obesity + endothelial dysfunction + hypercoagulability

Question 5

Prevention of macrovascular disease

Answer 5

blucose/bp/lipid control, weight loss/exercise, smoking cessation, aspirin, reduction of microalbuminuria

Question 6

Screening mnemonic PLAGUE F

Answer 6

pressure (Bp<7), urine (microalbumin/creatinine annually), eyes (annual dilated eye exam), feet (annual foot exam and neuropathy screening)

Question 7

Key finding of DCCT/EDIC trial

Answer 7

glycemic control in t1d improves micro and macrovascular outcomes

Question 8

Key finding of UKPDS trial

Answer 8

glycemic control in t2d improves micro and macrovascular outcomes

Question 9

Key finding of VADT/ACCORD/ADVANCE trial

Answer 9

near normal glycemic control in patients with long-standing t2d and multiple cardiac risk factors does not prevent cv events