Feast or Famine Flashcards
leptin
signal from adipose to hypothalamus–> increase alpha msh –> satiety, thermogenesis, fatty acid oxidation, insulin sensitivity
alpha msh works through which receptor?
mc4r - melanocortin4
deletion of the mc4r would result in what?
weight gain because of loss of leptin feedback
T/F G6 phosphatase is in the muscle and liver
F –> only liver; muscle does not export glucose
What is the consequence of losing leptin?
loss of feedback inhibition on brain –> obesity
T/F obesity can be monogenically determined
T–> can have congenital absence of leptin or mcr4r but for most it is an interplay of multiple genes and environment
T/F the larger your waist size, the greater your risk of coronary heart disease
T
Orlistat MOA
pancreatic lipase inhibitor –> reduced fat absorption –> steatorrhea
T/F RYGB reverses sleep apnea
T
T/F RYGB decreases cancer
T
T/F RYGB decreases diabetes
T
Adverse effects of RYGB
postop complications, vitamin/iron/ca deficiency, flatulence, recurrent severe hypoglycemia
T/F newborns produce more ketones than adults during fasting
T –> better at handling ketones
cachexia
wasting syndrome is loss of weight, muscle atrophy, fatigue, weakness, and significant loss of appetite –> inflammatory condition
Tx of cachexia
controlled refeeding, dx underlying diseases, anabolic tx: megesterol, cannabis, myostatin inhibitors (follistatin), ghrh
