Type 2 Diabetes Flashcards

1
Q

Pathophysiology of T2DM

A

Repeated exposure to glucose + insulin —> B cells hyperplasia/hypertrophy —> resistance

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2
Q

Risk factors

A
  • modifiable

- non-modifiable

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3
Q

Presentation

A

Similar to T1DM (excluding ketogenesis symptoms)

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4
Q

Timing of the day to perform OGTT

A

Prior to breakfast

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5
Q

HbA1c in pre diabetics

A

42-47 mmol/mol

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6
Q

Fasting glucose in pre-diabetics

A

6.1-6.9 mmol/l

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7
Q

OGTT in pre-diabetics

A

7.8-11 mmol/l

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8
Q

HbA1C in diabetics

A

> 48 mmol/mol

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9
Q

Random glucose in diabetics

A

> 11 mmol/l

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10
Q

Fasting glucose in diabetics

A

> 7 mmol/l

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11
Q

OGTT in diabetics

A

> 11 mmol/l

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12
Q

Dietary modifications to manage T1DM

A
  • vegetables + oily fish

- low sugar, high fibre diet

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13
Q

How can T2DM be curable

A
  • right lifestyle changes

- management of side effects

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14
Q

HbA1C target for a new T2DM diagnosis

A

48 mmol/mol

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15
Q

HbA1C in diabetics who moved beyond metformin

A

53 mmol/mol

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16
Q

1st line medication for T2DM

A

Metformin

17
Q

2nd line medication(s) for T2DM

A
  • sulfonylurea
  • pioglitazone
  • DPP-4 inhibitor
  • SGLT-2 inhibitor
18
Q

2 options for 3rd line for T2DM

A
  • Triple therapy (metformin + 2 2nd line)

- metformin + insulin

19
Q

Medications used in CVD

A

SGLT-2 inhibitors + GLP-1 mimetics

20
Q

sign at intertriginous site folds indicative of T2DM that is seen in gastric cancer

A

acanthosis nigricans

21
Q

2 mechanisms of complications due to T2DM

A
  • non-enzymatic glycation

- sorbitol accumulation

22
Q

rare artery to be artherosclerosed that is seen in diabetes

A

renal efferent arteriole

23
Q

How to distinguish diabetic neuropathy from other neuropathies

A

diabetic neuropathy better proximally & worse distally

24
Q

make cards on hyperosmolality symptoms

A

okay