Hypothyroidism

Question 1

Definition of hypothyroidism

Answer 1

Inadequate thyroid output

Question 2

Most common cause of hypothyroidism in the developed world

Answer 2

Hashimoto’s thyroiditis

Question 3

Abs found in hashimoto’s

Answer 3

• anti thyroid peroxide (anti-TPO)

- antithyroglobulin

Question 4

Presentation of Hashimoto’s

Answer 4

• initial goitre

- thyroid atrophy

Question 5

Most common cause of hypothyroidism in the developing world

Answer 5

Iodine deficiency

Question 6

Medications that can cause hypothyroidism

Answer 6

• lithium

- amiodarone

Question 7

Central causes of hypothyroidism (2ry)

Answer 7

Hypopituitarism (pituitary fails to produce enough TSH

Question 8

Causes of hypopituitarism

Answer 8

• tumours
• infection
• vascular
• radiation

Question 9

Hyperthyroidism tx options that can lead to hypothyroidism (4)

Answer 9

• carbimazole
• propylthiouracil
• radioactive iodine
• thyroid surgery

Question 10

(Shared) Presentations of hypothyroidism

Answer 10

• fatigue
• coarse hair/ hair loss
• heavy/irregular periods

Question 11

Weight changes in hypothyroidism

Answer 11

Weight gain

Question 12

Skin changes in hypothyroidism

Answer 12

Dry skin

Question 13

Fluid changes in hypothyroidism

Answer 13

Fluid retention

Question 14

Bowel changes in hypothyroidism

Answer 14

Constipation

Question 15

Investigations

Answer 15

Make sure to include in investigations deck

Question 16

Pathology & findings in 1ry (thyroid insufficiency)

Answer 16

• insufficient T3+T4 —> low

- -ve feedback —> high TSH

Question 17

Pathology in 2ry (pituitary insufficiency)

Answer 17

• low TSH —> low T3+T4

Question 18

Hypothyroidism tx

Answer 18

Oral Levothyroxine

Question 19

If dose is too high/low

Answer 19

Adjust

Question 20

UL sybdrome associated with hypothyroidism, weight gain and depression

Answer 20

Carpal tunnel