Hyperparathyroidism Flashcards
1
Q
Cells in PTH gland where PTH released from
A
Chief cells
2
Q
Trigger for PTH release
A
Hypocalcaemia
3
Q
Impact of PTH on osteoclast activity
A
+ activity —> + bone resorption
4
Q
PTH increases Ca2+ uptake from what two organs
A
- gut
- kidneys
5
Q
Impact of PTH on VitD activity
A
+ activity —> + Ca absorption from intestines
6
Q
Two molecules needed for Ca absorption
A
VitD + PTH
7
Q
4 symptoms of hypercalcaemia (rhymes)
A
- renal stones
- painful bones
- abdominal groans
- psychiatric moans
8
Q
Aetiology of 1ry hyperPTH
A
Uncontrolled PTH production
9
Q
Cause of 1ry hyperPTH
A
PT gland tumour
10
Q
HyperPTH tx
A
Surgery
11
Q
Aetiology of 2ry hyperPTH
A
Low Ca absorption
12
Q
Cause of 2ry hyperPTH
A
Insufficient VitD/chronic renal failure
13
Q
Pathophysiology of 2ry hyperPTH
A
- PT glands hyperplasia
- low Ca —> ++PTH
14
Q
2ry hyperPTH tx
A
- correct VitD deficiency
- correct renal function
- calcimimetics
15
Q
Aetiology of 3ry hyperPTH
A
Dramatic +++ in baseline PTH levels
