Type 1 Metabolic Syndrome

Question 1

when is the onset?

Answer 1

early age

*exception: LADA

Question 2

what happens to beta cells?

Answer 2

there is progressive autoimmune destruction of beta cells (up to 90% destruction –> overt DM) = absolute insulin deficiency

Question 3

insulin _________ ___________ target ______ ______ _________

Answer 3

autoantibody production; beta cell antigens

Question 4

______ _______ autoantibody prod. targets ________ ___ __________ _________

Answer 4

islet cell; islets of Langerhans antigens (not just beta cells)

Question 5

insulitis

Answer 5

swollen/edematous islets of Langerhans d/t infiltration of lymphocytes