Tutorial Flashcards
1
Q
What does ATM + ATR do:
A
detect double strand breaks
2
Q
What activates p53- ATM or ATR:
A
ATM
3
Q
What does ATR do:
A
check damage -> chk1 + chk2 -> stop s/g2 -> does homologous recombination
4
Q
Chk1 job:
A
stop cell cycle
5
Q
PARP job:
A
fix single strand breaks by poly ADP ribose polymerase
6
Q
Why inhibit PARP?
A
Stop it so no single strand repair after chemo + radiotherapy
7
Q
Why is parp not enough to stop?
A
BRCA 2 -> makes BER
8
Q
Drug PARP inhibitor:
A
Olaparib
9
Q
Is cancer hetero/homogenous?
A
Heterogenous
10
Q
Molecular heterogeneity:
A
> transcription profiles
11
Q
Cellular heterogeneity:
A
> cells
12
Q
Regional heterogeneity:
A
> regions
13
Q
PD-L1 in cancer:
A
overexpressed
14
Q
EFGR:
A
receptor in exon 18-21 -> RAS mutation -> constantly binding tyrosine kinase
15
Q
How does EFGR adapt:
A
mutation threonine -> methionine (drug cant bind)
