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Pathology > Tumour Mutations > Flashcards

Tumour Mutations Flashcards

1
Q

Glioblastoma

A 
PTEN 
Delete chromosome 10
Amaplify EGFR oncogene 
-increased RTK
Delete 9p21
0inhibits RB and p53
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2
Q

Proneural glioblastoma

A

Tp53 in IDH1 and IDH2

Overexpressed PDGFRA
-increased RTK

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3
Q

Neural glioblastoma

A

NEFL, GABRA1, SYT1, SLC12A5

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4
Q

Mesenchymal glioblastoma

A

Delete NF1 on 17

Overexpression TNF NFkB

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5
Q

Better prognosis glioblastoma

A

IDH1

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6
Q

Pilocytoc astrocytoma

A

BRAF

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7
Q

Oligodendroglioma better prognosis

A

IDH1 IDH2

Co delete 1p 19q

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8
Q

Gangliomas

A

BRAF like pilocytic astrocytoma

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9
Q

Medulloblastoma

A

WNT-6best

SHH-infants MYC amplification

Group 3 back MYC amp

Group 4-medulloblastoma no MYC sometimes nMYC

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10
Q

Choriocarcinoma vs prostatic carcinoma

A

Goes to brain

Never goes to brain

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11
Q

Primary CNS lymphoma

A

AIDS/immune suppressed
EBV
Organ transplant-lymphoproliferative disorder
Aggressive when primary

Hopping “infiltrating cells are separated from one another by silver staining

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12
Q

Myxopapillary ependymomas

A

In film terminals

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13
Q

Xanthoastrocytoma

A

Temporal lobe of kids

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Pathology (36 decks)

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