Antibiotics Final

Question 1

Bacteriocidal

Answer 1

Kill

Question 2

Bacteriostatic

Answer 2

Prevent growth

Question 3

Describe penicillin

Answer 3

Thiazolidine ring with beta Lactation rings with R groups(for modifications)
Inhibit cell wall synthesis by inhibiting penicillin binding protein/transpeptidase, inhibiting peptidoglycan cell wall cross linking
ONLY WORKS ON ACTIVELY GROWING CELLS

Question 4

How become resistant to penicillin

Answer 4

Alter porins, alter structure of Pbp/transpeptidase, upregulate penicillin pumps

Porins are how they get into bacteri a
Pump get them out

Question 5

Penicillin G

Answer 5

1st
Competitively compete with transpeptidase->bacteriocidal

Many organisms resistant
Use on-S pneumonia, s pyogenes, viridans, N mengitidites, spirochetes, C perfrigens
(Gram positive organisms, gram negative cocci, non beta lactamase producing anaerobes

Can get hypersensitivity reactions