Tumour immunity Flashcards
1
Q
What is tumour surveillance?
A
Immunosurveillance system
Eradicates tumours before they grow
2
Q
Tumour cells may be different enough from their original cell that they can be targeted by the immune system. What 3 major cells are involved in tumour immunity?
A
CMN
Cytotoxic CD8+ T cell
Macrophage
Natural killer cell
3
Q
Are tumour antigens present on all tumour cells?
A
No- many tumours induce tolerance
4
Q
How do tumour associated macrophages (TAMs) affect tumour growth?
A
May protect against growth
However they can be under the control of the tumour = allow growth
5
Q
How do tumours escape immune mechanisms?
A
Cause low immunogenicity
Antigen modulation
Induce lymphocyte apoptosis
Suppress anti-tumour response
