Tumor Viruses

Question 1

What are oncogenes?

Answer 1

Cellular genes activated in tumor cells and/or growth factor and growth factor receptors.

Question 2

Is a tumor a genetic disease?

Answer 2

Sometimes

Question 3

What are proto-oncogenes?

Answer 3

Normal genes that become oncogenic due to increased expression and/or mutations

Question 4

What are viral oncogenes?

Answer 4

Viral genes that act as tumor inducers

Question 5

What is phase of the cell cycle is a cell in when the chromosome is being duplicated?

a. G1 phase
b. G0 phase
c. S phase
d. M phase

Answer 5

C.

Question 6

What is the cycling needed to trigger the transition from G1 to S phase?

a. Cyclin D
b. Cyclin E
c. Cyclin A
d. Cyclin B

Answer 6

A.

A litte of B.

Question 7

What subfamilies of herpesviruses are possibly associated with tumors?

Answer 7

Gammaherpesviruses

Question 8

What is transformation?

Answer 8

Normal cell phentoype that is changes to an abnormal, oncogenic phenotypes due to something happening the genome or gene expression from stimuli. These cells divide uncontrollably

Question 9

How do the RNA tumor viruses transform cells?

Answer 9

Onc + or Onc - encode for growth factors, growth factor receptors, signal transduction proteins, and/or transcription factors

Question 10

How do DNA tumor viruses transform cells?

Answer 10

By interfering with tumor suppressors like pRB and p53. Can also interfere with transcription factors.

Question 11

What proteins do oncogenes encode?

Answer 11

1. Growth factors
2. Growth factor receptors
3. Signal transduction proteins
4. Transcription factors

Question 12

What is retinoblastoma protein?

a. Viral protein
b. Cytokine
c. Kinase
d. Cell cycle regulator
e. Tumor suppressor protein

Answer 12

D. and E.

Question 13

What is p53?

Answer 13

A tumore suppressor protein