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Virology > Rhabdoviridae > Flashcards

Rhabdoviridae Flashcards

1
Q

What is in negri bodies and what occurs here?

A

Fully assembled or partly assembled virions, many rabies virus structural proteins, and RNA polymerase. This is where virus replication occurs.

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2
Q

What are the two forms and symptoms of a rabies virus infection?

A
  1. Dumb: Neocortex infected causing paralysis, coma and death.
  2. Furious: Limbic system infected causing encephalitis, muscle tremors, ataxia, hydrophobia, dysphagia, and aggression.
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3
Q

What is the genome of rhabdoviridae

A

-ssRNA

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4
Q

Is Rhabdoviridae enveloped or nonenveloped?

A

Enveloped

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5
Q

What type of tissue do rabies viruses infect?

A

Neurons, muscle cells and salivary glands

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6
Q

What tissues need to be evaluated to properly diagnose rabies?

A

Brainstem and cerebellum

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7
Q

Is there any gross pathology associated with rabies virus infection?

A

NO

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8
Q

Which viruses cause viral vesicular disease in livestock?

A
  1. Foot and mouth disease virus (picornar)
  2. Swine vesicular disease virus (picornar)
  3. Vesicular exanthema of swine virus (calici)
  4. Vesicular stomatitis virus (Rhabdo)
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9
Q

What is a Negri body?

a. Inclusion body in the nucleus
b. Inclusion body in the cytoplasm
c. Inclusion body in the neurons
d. Inclusion body in the oligocytes

A

B.

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10
Q

Which protein is important for entry of rabies virus?

A

G proteins…surface glycoproteins

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11
Q

What are the species affected by viral vesicular disease?

A

Cattle, sheep, horses and swine

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12
Q

What is common between viral vesicular disease and rabies?

A

The viruses have the same morphology, genome and replication strategy, but they infect different tissue.

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13
Q

What type of disease is associated with VSV infection?

A

Excessive salivation

Vesicles on mouth, muzzle and snout.

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14
Q

What is the capsid shape for Rhabdoviridae?

What is the shape of the virion?

A

Helical

Bullet with spike surface proteins

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15
Q

Is the genome of rhabdoviridae segmented or nonsegmented?

A

Non-segmented

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16
Q

Is the genome capable of RNA editing?

What other virus does this that we learned about?

A

Yes

Paramyxoviridae

17
Q

How do rhabdoviruses enter a host cell?

A

Attach to receptors such as nicotinic acetylcholine receptors and neural cell adhesion molecule CD56 , then pinocytosis/endocytosis occurs…all mediated by G proteins.

18
Q

What is the incubation times for the rabies virus?

A

9 days to 2 months or longer (7 years)

19
Q

How can variants in the genotype of the rabies virus be differentiated?

A

Antibody response or PCR

20
Q

What is the pathogenesis of the rabies virus?

A

Bit wound- virus multiplies in myocytes- travels up peripheral nerves to CNS-multiplies in the CNS- moves out of peripheral nerves to salivary gland, skin, mucosal surface, the GI, and other organs.

21
Q

What test should be done on animals suspected for rabies?

A

Direct fluorescent antibody test (FA)

22
Q

What rabies vaccines are used in animals and humans?

A

Animal: live and killed vaccines
Human: killed vaccine grown in human fibroblasts

23
Q

How can you treat human that may have been infected with rabies?

A

Rabies immune globulin injected

24
Q

What is the only vesicular virus that infects horses called?

A

Vesicular stomatitis virus (VSV)

25
Q

Is vesicular stomatitis virus zoonotic?

A

YES

26
Q

How is VSV transmitted?

A
  1. Vectors

2. Horizontal via saliva, exudates or epithelium of open vesicles, soil , and plants

27
Q

How is vesicular stomatitis virus diagnosed?

A
  1. Virus isolation via RT-PCR
  2. Serum neutralization
  3. ELISA
28
Q

Is there a vaccine for VSV?

A

NO, need to quarantine infected animals.

29
Q

What is important to know about VSV in horses?

A

It is on the OIE A list and is zoonotic.

30
Q

What viruses cause viral vesicular disease?

A
  1. Vesicular exanthema of swine…calcivirus

2. VSV..rhabdovirus

Virology (12 decks)

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