Papovaviridae

Question 1

Is dermal layer permissive for papillomavirus infection?

Answer 1

Semi-permissive

Question 2

How do we define the types of Papillomaviruses?

Answer 2

Serologic cross reactivity or restriction endonuclease cleavage

Question 3

What is the difference between equine papilloma and equine sarcoid?

Answer 3

Location. Papillomas are usually in mouth/uzzle region and sarcoids can be anywhere.

Question 4

What is the age group most commonly affected by equine Sarcoids?
What about papillomas?

Answer 4

3-6 years

1-3 years

Question 5

Are papillomaviruses DNA or RNA viruses?

Answer 5

DNA

Question 6

Are papillomaviruses enveloped or nonenveloped?

Answer 6

Non-enveloped

Question 7

What effect do E6 or E7 gene products have on cell cycle regulation?

Answer 7

They inhibit tumor suppressor proteins and allow the cell cycle to continue.

Question 8

What does Onc+ virus mean to you?

a. Tumor virus
b. Retrovirus that can cause cancer
c. DNA tumor virus that can cause cancer
d. Retrovirus that carries viral oncogene

Answer 8

D.

Question 9

How do the RNA tumor viruses transform cells?

Answer 9

Secrete/alter growth factors, growth factor receptors, transcription factors, and alter signaling patterns.

Question 10

How do papillomaviruses cause tumors

a. They carry oncogenes
b. They encode E6 or E7 that can stimulate cell dividing
c. They produce growth factors which can stimulate cell growth
d. They encode E6 or E7 that can inactivate tumor suppressor function and lead to unregulated cell cycling

Answer 10

D.