Tumor Supressor Genes Flashcards by Kelly Stewart | Brainscape

Q

APC

A

Colorectal Cancer (associated with FAP)

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Q

BRCA1/BRCA2

A

DNA Repair Protein

Breast and Ovarian Cancer

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Q

CDKN2A

A

p16: Blocks G1 - S Phase

Melanoma and Pancreatic Cancer

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Q

DCC

A

Colon Cancer

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Q

DPC4/SMAD4

A

Pancreatic Cancer

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Q

MEN1

A

Menin

MEN1

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Q

NF1

A

Ras GTPase Activating Protein (neurofibromin)

Neurofibromatosis Type 1

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Q

NF2

A

Merlin (schwannomin) Protein

Neurofibromatosis Type 2

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Q

PTEN

A

Breast, prostate, and endometrial cancer

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Q

Rb

A

Inhibits E2F; Blocks G1 - S Phase

Retinoblastoma and Osteosarcoma

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Q

TP53

A

p53, Activates p21; Blocks G1 - S Phase

Most human cancers, Li-Fraumeni Syndrome

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Q

TSC1

A

Hamartin Protein

Tuberous Sclerosis

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Q

TSC2

A

Tuberin Protein

Tuberous Sclerosis

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Q

VHL

A

Inhibits hypoxia inducible factor 1A

Von-Hippel-Lindau Disease, Renal Cell Carcinoma

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Q

WT1/WT2

A

Wilms Tumor (Nephroblastoma)

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