Tumor Suppressor genes

Question 1

APC

Answer 1

Assoc. condition: colorectal cancer (assoc. with FAP)

Gene product: Negative regulator of b-catenin, WNT pathway

Question 2

BRCA1/BRCA2

Answer 2

Assoc. condition: breast and ovarian cancer

Gene product: DNA repair protein

Question 3

CDKN2A

Answer 3

Assoc. condition: melanoma, pancreatic cancer

Gene product: p16, blocks G1 –> S phase

Question 4

DCC

Answer 4

Assoc. condition: colon cancer

Gene product: DCC - Deleted in Colon Cancer

Question 5

DPC4/SMAD4

Answer 5

Assoc. condition: pancreatic cancer

Gene product: DPC - Deleted in Pancreatic Cancer

Question 6

MEN1

Answer 6

Assoc. condition: MEN1

Gene product: menin

Question 7

NF1

Answer 7

Assoc. condition: neurofibromatosis type 1

Gene product: Ras GTPase activating protein (neurofibromin)

Question 8

NF2

Answer 8

Assoc. condition: neurofibromatosis type 2

Gene product: merlin (schwannomin) protein

Question 9

PTEN

Answer 9

Assoc. condition: breast cancer, prostate cancer, endometrial cancer
Gene product: tyrosine phosphatase of PIP3 (e.g. protein kinase B [AKT] activation)

Question 10

Rb

Answer 10

Assoc. condition: retinoblastoma, osteosarcoma

Gene product: inhibits E2F, blocks G1 –> S phase

Question 11

TP53

Answer 11

Assoc. condition: most human cancer, (Sarcoma, Breast, Leukemia, Adrenal gland), Li-Fraumeni syndrome
Gene product: p53, activates p21, blocks G1 –> S phase

Question 12

TSC1

Answer 12

Assoc. condition: tuberous sclerosis

Gene product: hamartin protein

Question 13

TSC2

Answer 13

Assoc. condition: tuberous sclerosis

Gene product: tuberin protein

Question 14

VHL

Answer 14

Assoc. condition: von Hippel-Lindau dz, renal cell carcinoma

Gene product: inhibits hypoxia inducible factor 1a

Question 15

WT1/WT2

Answer 15

Assoc. condition: Wilms tumor (nephroblastoma)

Gene product: transcription factor that regulates urogenital development