Oncogenes

Question 1

ALK

Answer 1

Gene product: receptor tyrosine kinase

Neoplasm: Lung adenocarcinoma

Question 2

BCR-ABL

Answer 2

Gene product: tyrosine kinase

Neoplasm: CML, ALL

Question 3

BCL-2

Answer 3

Gene product: Antiapoptotic molecule (inhibits apoptosis)

Neoplasm: Follicular and diffuse large B cell lymphomas

Question 4

BRAF

Answer 4

Gene product: serine/threonine kinase

Neoplasm: melanoma, non-Hodgkin lymphoma

Question 5

c-KIT

Answer 5

Gene product: cytokine receptor

Neoplasm: gastrointestinal stromal tumor (GIST)

Question 6

c-MYC

Answer 6

Gene product: transcription factor

Neoplasm: Burkitt lymphoma

Question 7

HER2/neu (c-erbB2)

Answer 7

Gene product: tyrosine kinase

Neoplasm: breast and gastric carcinomas

Question 8

JAK2

Answer 8

Gene product: tyrosine kinase

Neoplasm: chronic myeloproliferative d/o

Question 9

KRAS

Answer 9

Gene product: GTPase

Neoplasm: colon cancer, lung cancer, pancreatic cancer

Question 10

MYCL1

Answer 10

Gene product: transcription factor

Neoplasm: lung tumor

Question 11

MYCN

Answer 11

Gene product: transcription factor

Neoplasm: neuroblastoma

Question 12

RET

Answer 12

Gene product: tyrosine kinase

Neoplasm: MEN 2A and 2B, medullary thyroid cancer