Important cytokines Flashcards
IL-1
Fever and acute inflammation
osteoclast-activating factor
IL-2
Stimulates T cells
IL-3
Stimulates bone marrow
IL-4
Stimulates IgE production
Promotes growth of B cells
IL-5
Stimulates IgA production
Stimulates growth and differentiation of eosinophils
IL-6
Stimulates acute-phase protein production
IL-8
Major chemotactic factor for neutrophils
IL-10
Attenuates inflammatory response.
Inhibits activated macrophages and dendritic cells
IL-12
Induces differentiation of T cells into Th1 cells. Activates NK cells
TNF-a
Mediates septic shock. Activates endothelium. Causes WBC recruitment, vascular leak
IFN-g
Stimulates macrophages to kill phagocytosed pathogens
Inhibits differentiation of Th2 cells
IFN-a & IFN-b
Interfere with viruses (innate host defense)
TGF-b
Attenuate the immune response
