Autoantibodies

Question 1

Anti-ACh receptor

Answer 1

Myasthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin, lupus anticoagulant

Answer 3

SLE, antiphospholipid syndeom

Question 4

Anticentromere

Answer 4

Limited scleroderma (CREST syndrome)

Question 5

Anti-desmoglein (anti-desmosome)

Answer 5

Pemphigus vulgaris

Question 6

Anti-dsDNA, anti-Smith

Answer 6

SLE

Question 7

Anti-glutamic acid decarboxylase (GAD-65)

Answer 7

Type 1 diabetes mellitus

Question 8

Antihemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Anti-histone

Answer 9

Drug-induced SLE (hydralazine)

Question 10

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 10

Polymyositis, dermatomyositis

Question 11

Antimicrosomal, antithyroglobulin

Answer 11

Hashimoto thyroiditis

Question 12

Antimitochondrial

Answer 12

Primary biliary cirrhosis

Question 13

Antinuclear (ANA)

Answer 13

SLE, nonspecific

Question 14

Antiparietal cell

Answer 14

Pernicious anemia

Question 15

Antiphospholipase A2 receptor

Answer 15

Primary membranous nephropathy

Question 16

Anti-Scl-70 (anti-DNA topoisomerase 1)

Answer 16

Scleroderma (diffuse)

Question 17

Anti-smooth muscle

Answer 17

Autoimmune hepatitis type 1

Question 18

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 18

Sjogren syndrome

Question 19

Anti-TSH receptor

Answer 19

Graves dz

Question 20

Anti-U1 RNP (ribonucleoprotein)

Answer 20

Mixed connective tissue dz

Question 21

Voltage-gated calcium channel antibodies

Answer 21

Lambert-Eaton syndrome

Question 22

IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 22

Celiac dz

Question 23

MPO-ANCA

p-ANCA

Answer 23

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Question 24

PR3-ANCA

c-ANCA

Answer 24

Granulomatosis with polyangiitis (Wegener)

Question 25

Rheumatoid factor (IgM antibody that targets IgG Fc region), anti-CCP (more specific)

Answer 25

Rheumatoid arthritis