Tumor markers Flashcards
Alkaline phosphatase
Mets to bone or liver, Paget dz of bone, seminoma (placental ALP)
a-fetoprotein
Hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, mixed germ cell tumor.
High levels associated with neural tube and abdominal wall defects. Low levels associated with Down syndrome
b-hCG
Hydatidiform moles and choriocarcinomas (gestational trophoblastic dz), testicular cancer, mixed germ cell tumor
CA 15-3
CA 27-29
Breast cancer
CA 19-9
Pancreatic adenocarcinoma
CA 125
Ovarian cancer
Calcitonin
Medullary thyroid carcinoma
CEA
CarcinoEmbryonic Antigen
Very nonspecific, produced by 70% of colorectal and pancreatic cancers, also produced by gastric, breast, and medullary thyroid carcinomas
PSA
Prostate-specific antigen. Prostate cancer
Can be elevated in BPH and prostatitis