Tumor markers Flashcards

1
Q

Alkaline phosphatase

A

Mets to bone or liver, Paget dz of bone, seminoma (placental ALP)

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2
Q

a-fetoprotein

A

Hepatocellular carcinoma, hepatoblastoma, yolk sac (endodermal sinus) tumor, mixed germ cell tumor.
High levels associated with neural tube and abdominal wall defects. Low levels associated with Down syndrome

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3
Q

b-hCG

A

Hydatidiform moles and choriocarcinomas (gestational trophoblastic dz), testicular cancer, mixed germ cell tumor

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4
Q

CA 15-3

CA 27-29

A

Breast cancer

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5
Q

CA 19-9

A

Pancreatic adenocarcinoma

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6
Q

CA 125

A

Ovarian cancer

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7
Q

Calcitonin

A

Medullary thyroid carcinoma

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8
Q

CEA

A

CarcinoEmbryonic Antigen
Very nonspecific, produced by 70% of colorectal and pancreatic cancers, also produced by gastric, breast, and medullary thyroid carcinomas

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9
Q

PSA

A

Prostate-specific antigen. Prostate cancer

Can be elevated in BPH and prostatitis

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