Tumor Suppressor Genes Flashcards by Ryan Bray | Brainscape

Q

Retinoblastoma?

A

Rb

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Q

Osteosarcoma?

A

Rb

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Q

Li-Fraumeni?

A

p53

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Q

Breast and ovarian?

A

BRCA1 and 2

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Q

Melanoma?

A

p16, BRAF

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Q

Colorectal cancer (assoc with FAP)?

A

APC

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Q

Wilm’s tumor (nephroblastoma)?

A

WT1

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Q

Pancreatic cancer?

A

DPC4 (Deleted in Pancreatic Cancer)

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Q

Colon cancer?

A

DCC (Deleted in Colon Cancer)

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Q

Rb?

A

Inhibits E2F; blocks G1–>S phase

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Q

p53?

A

Txc factor for p21, blocks G1–>S phase

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Q

BRCA1 and 2?

A

DNA repair protein

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Q

NF1?

A

RAS GTPase activating protein (RAS-GAP)

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Q

NF2?

A

Merlin (schwannomin) protein

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Q

What Chr is Rb found?

A

Chr 13

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Q

What Chr is p53 found?

A

Chr 17