Chemical Carcinogens Flashcards
Aflatoxins (Aspergillus)?
HCC
Vinyl chloride?
Angiosarcoma of liver
Carbon tetrachloride?
Centrilobular necrosis, fatty change
Nitrosamines (smoked foods)?
Gastric cancer
Cigarette smoke?
SCC of larynx and lung, small cell of lung, RCC, transitional cell carcinoma, pancreatic adenocarcinoma
Asbestos?
Bronchogenic carcinoma > mesothelioma
Arsenic?
SCC of skin, angiosarcoma of liver
Naphthalene (aniline) dyes?
Transitional cell carcinoma
Alkylating agents?
Leukemia
Alcohol?
SCC of oropharynx and upper esophagus, pancreatic carcinoma, and HCC
Nickel, chromium, beryllium, or silica?
Lung carcinoma (occupational exposure)
Most common carcinogen worldwide?
Cigarette smoke–polycyclic hydrocarbon especially
Key carcinogen causing bladder carcinoma?
Cigarette smoke