Paraneoplastic Syndromes

Question 1

ACTH or ACTH-like peptide causing Cushing’s syndrome?

Answer 1

Small cell lung carcinoma

Question 2

ADH causing SIADH?

Answer 2

Small cell lung carcinoma and intracranial neoplasms

Question 3

PTH-rP causing hypercalcemia?

Answer 3

SCC of lung, RCC, breast cancer

Question 4

1,25-(OH)2 D3 (calcitriol) causing hypercalcemia?

Answer 4

Hodgkin’s, some non-Hodgkin’s

Question 5

EPO causing polycythemia?

Answer 5

RCC, hemangioblastoma, HCC, pheochromocytoma

Question 6

Abs against presynaptic Ca channels at NMJ?

Answer 6

Small cell of lung (causes Lambert-Eaton syndrome)