Misc Path

Question 1

Eliminates O2 free radical?

Answer 1

Superoxide dismutase

Question 2

Eliminates OH free radical

Answer 2

Gutathione peroxidase

Question 3

Eliminates H202?

Answer 3

Catalase

Question 4

Types of systemic amyloidosis?

Answer 4

Primary (AL) and secondary (AA)

Question 5

Derived from Ig light chain?

Answer 5

Primary (AL)

Question 6

Diseases assoc with primary AL?

Answer 6

Plasma cell dyscrasias and multiple myeloma

Question 7

What is secondary AA derived from?

Answer 7

Serum amyloid A (SAA)–acute phase reactant that is increased in chronic inflammatory states (RA, IBD, spondyloarthropathies, chronic infection), malignancy

Question 8

Familial Mediterranean fever?

Answer 8

Secondary AA

Question 9

S/S of FMF?

Answer 9

Episodes of fever and acute serosal inflammatio (mimics MI and acute appendicitis)

Question 10

Most common organ affected by amyloid?

Answer 10

Kidney (nephrotic syndrome)

Question 11

Non-mutated (wild type) serum transthyretin deposits?

Answer 11

Senile cardiac amyloidosis–usually asxs

Question 12

Mutated serum transthyretin?

Answer 12

Familial amyloid cardiomyopathy–leads to restrictive cardiomyopathy

Question 13

Amylin deposits in islets of pancreas?

Answer 13

T2DM–derived from insulin

Question 14

Derived from B-amyloid precursor protein?

Answer 14

Alzheimer’s

Question 15

B2 microglobulin deposits?

Answer 15

Dialysis-assoc amyloidosis

Question 16

What is B2 microglobulin a component of?

Answer 16

MHC class I

Question 17

S/S of dialysis assoc amyloidosis?

Answer 17

Carpal tunnel and other joint issues

Question 18

Calcitonin deposits within tumor?

Answer 18

Medullary carcinoma of thyroid