Tumor Suppressor Genes Flashcards by Jamie Pytel | Brainscape

Q

APC

A

Colorectal cancer (FAP)

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Q

BRCA1/BRCA2

A

Breast and ovarian cancer

DNA repair protein

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Q

DCC

A

Colon cancer

DCC: Deleted in Colon Cancer

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Q

DPC4/SMAD4

A

Pancreatic cancer

DPC: Delted in Pancreatic Cancer

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Q

MEN1

A

MEN 1

Menin

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Q

NF1

A

Neurofibromatosis type 1

Ras GTPase activating protein (neurofibromin)

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Q

NF2

A

Neurofibromatosis type 2

Merlin (schwannomin) protein

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Q

p16

A

Melanoma

Cyclin-dependent kinase inhibitor 2A

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Q

p53

A

Most human cancers, Li-Fraumeni syndrome

Transcription factor for p21, blocks G1-S phase

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Q

PTEN

A

Breast cancer, prostate cancer, endometrial cancer

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Q

Rb

A

Retinoblastoma, osteosarcoma

Inhibits E2F; blocks G2-S phase

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Q

TSC1

A

Tuberous sclerosis

Hamartin protein

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Q

TSC2

A

Tuberous sclerosis

Tuberin protein

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Q

VHL

A

von Hippel-Lindau disease, renal cell carcinoma

Inhibits hypoxia inducible factor 1a

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Q

WT1/WT2

A

Wilms tumor (nephroblastoma)

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